This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Droz, D. Articles by Iris, L. Search for Related Content PubMed PubMed Citation Articles by Droz, D. Articles by Iris, L.

American Journal of Pathology, Vol 137, 895-905, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of the human nephron differentiation molecules in renal cell carcinomas

D Droz, D Zachar, L Charbit, J Gogusev, Y Chretein and L Iris
Nephrology Clinic, Necker Hospital, Paris, France.

The authors tested frozen sections from 28 renal cell carcinomas (RCC)-- 21 clear, 1 eosinophilic, 4 basophilic, and 2 spindle-shaped cell type-- with monoclonal antibodies (MAb) reacting against cytokeratin, vimentin, CD24, CALLA/CD10, villin, CD26, and HLA class I and class II molecules. These molecules are markers of specific segments of the mature kidney, and their loss or acquisition reflects the different steps of human nephrogenesis. KI67 MAb was used to evaluate cell- proliferating activity. All RCC cases expressed cytokeratin. Coexpression of vimentin was observed in 21 of 28 cases. Whether of clear or chromophilic type, all tumoral cells strongly expressed CD24 molecule, present on primitive blastema cells. All clear-type RCCs expressed CALLA/CD10 and 60% were also villin positive; some were faintly positive for CD26. CALLA, villin, and CD26 were not detected in basophilic cell type. HLA class I molecules were variably expressed in almost all cases, but HLA class II were never detected on tumoral cells. Except for the spindle-shaped population, cell-proliferating activity was low. These results favor the hypothesis that RCCs derive from cells that have 'recovered' the different options of metanephric differentiation. Clear cells show evidence of maturation toward proximal type, while basophilic cells do not. It would be of interest to evaluate the usefulness of serum measurements of villin and/or CALLA as markers in clear cell-type RCC.

This article has been cited by other articles:

				T. Inamoto, T. Yamochi, K. Ohnuma, S. Iwata, S. Kina, S. Inamoto, M. Tachibana, Y. Katsuoka, N. H. Dang, and C. Morimoto Anti-CD26 Monoclonal Antibody-Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kip1 Enhancement, and Disruption of Binding to the Extracellular Matrix. Clin. Cancer Res., June 1, 2006; 12(11): 3470 - 3477. [Abstract] [Full Text] [PDF]

				P. Baumann, N. Cremers, F. Kroese, G. Orend, R. Chiquet-Ehrismann, T. Uede, H. Yagita, and J. P. Sleeman CD24 Expression Causes the Acquisition of Multiple Cellular Properties Associated with Tumor Growth and Metastasis Cancer Res., December 1, 2005; 65(23): 10783 - 10793. [Abstract] [Full Text] [PDF]

				W. Weichert, C. Denkert, M. Burkhardt, T. Gansukh, J. Bellach, P. Altevogt, M. Dietel, and G. Kristiansen Cytoplasmic CD24 Expression in Colorectal Cancer Independently Correlates with Shortened Patient Survival Clin. Cancer Res., September 15, 2005; 11(18): 6574 - 6581. [Abstract] [Full Text] [PDF]

				G M K Tse, A K H Tsang, T C Putti, R A Scolyer, P C W Lui, B K B Law, R Z Karim, and C S Lee Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours J. Clin. Pathol., February 1, 2005; 58(2): 185 - 189. [Abstract] [Full Text] [PDF]

				G. A. Challen, G. Martinez, M. J. Davis, D. F. Taylor, M. Crowe, R. D. Teasdale, S. M. Grimmond, and M. H. Little Identifying the Molecular Phenotype of Renal Progenitor Cells J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2344 - 2357. [Abstract] [Full Text] [PDF]

				G. Kristiansen, K.-J. Winzer, E. Mayordomo, J. Bellach, K. Schluns, C. Denkert, E. Dahl, C. Pilarsky, P. Altevogt, H. Guski, et al. CD24 Expression Is a New Prognostic Marker in Breast Cancer Clin. Cancer Res., October 15, 2003; 9(13): 4906 - 4913. [Abstract] [Full Text] [PDF]

				E. C. Ibrahim, Y. Allory, F. Commo, B. Gattegno, P. Callard, and P. Paul Altered Pattern of Major Histocompatibility Complex Expression in Renal Carcinoma: Tumor-Specific Expression of the Nonclassical Human Leukocyte Antigen-G Molecule Is Restricted to Clear Cell Carcinoma While Up-Regulation of Other Major Histocompatibility Complex Antigens Is Primarily Distributed in All Subtypes of Renal Carcinoma Am. J. Pathol., February 1, 2003; 162(2): 501 - 508. [Abstract] [Full Text] [PDF]

				G. Kristiansen, C. Denkert, K. Schluns, E. Dahl, C. Pilarsky, and S. Hauptmann CD24 Is Expressed in Ovarian Cancer and Is a New Independent Prognostic Marker of Patient Survival Am. J. Pathol., October 1, 2002; 161(4): 1215 - 1221. [Abstract] [Full Text] [PDF]

				E. C. Ibrahim, N. Guerra, M.-J. T. Lacombe, E. Angevin, S. Chouaib, E. D. Carosella, A. Caignard, and P. Paul Tumor-specific Up-Regulation of the Nonclassical Class I HLA-G Antigen Expression in Renal Carcinoma Cancer Res., September 1, 2001; 61(18): 6838 - 6845. [Abstract] [Full Text] [PDF]

				A. Nestl, O. D. Von Stein, K. Zatloukal, W.-G. Thies, P. Herrlich, M. Hofmann, and J. P. Sleeman Gene Expression Patterns Associated with the Metastatic Phenotype in Rodent and Human Tumors Cancer Res., February 1, 2001; 61(4): 1569 - 1577. [Abstract] [Full Text]