This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Feichtinger, H. Articles by Biberfeld, P. Search for Related Content PubMed PubMed Citation Articles by Feichtinger, H. Articles by Biberfeld, P.

American Journal of Pathology, Vol 137, 1311-1315, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus

H Feichtinger, P Putkonen, C Parravicini, SL Li, EE Kaaya, D Bottiger, G Biberfeld and P Biberfeld
Immunopathology Laboratory, Karolinska Institute, Stockholm, Sweden.

Malignant lymphomas were observed in 38% (9 of 24) of simian immunodeficiency virus (SIV)-infected cynomolgus monkeys (Macaca fascicularis) 5 to 15 months after inoculation with SIV strain SMM3. Lymphomagenesis in the SIV-infected monkeys was not related directly to the SIV-infectious dose given. All SIV-infected animals developed severe immunodeficiency. No significant difference in immunodeficiency was observed between tumor-bearing and non-tumor-bearing animals. In contrast, no lymphomas were observed in a comparable group of HIV-2- infected monkeys, which did not develop immunodeficiency; nor did the noninfected control monkeys. All 9 SIV-related tumors were high-grade B- cell lymphoblastic or pleomorphic lymphomas with extranodal, disseminated growth. Most tumors showed marked infiltration by monocytes and CD8+ T lymphocytes. Occasional tumor infiltrating cells showed immunohistochemical reaction for SIV. The cells of two tumors were established in vitro and shown to be of B-cell phenotype. The tumor cell cultures showed no reverse transcriptase activity and no evidence of virus infection by electron microscopy. Our observations indicate that SIV-induced immunodeficiency in cynomolgus monkeys also mimics HIV infection and AIDS in humans with regard to increased lymphomagenesis and type of lymphomas.

This article has been cited by other articles:

				Y. A. Paramastri, J. M. Wallace, K. J. Salleng, L. M. Wilkinson, D. E. Malarkey, and J. M. Cline Intracranial Lymphomas in Simian Retrovirus-Positive Macaca fascicularis Vet. Pathol., May 1, 2002; 39(3): 399 - 402. [Abstract] [Full Text] [PDF]

				K. Kahnt, K. Matz-Rensing, P. Hofmann, C. Stahl-Hennig, and F.-J. Kaup SIV-associated Lymphomas in Rhesus Monkeys (Macaca mulatta) in Comparison with HIV-associated Lymphomas Vet. Pathol., January 1, 2002; 39(1): 42 - 55. [Abstract] [Full Text] [PDF]

				Y.-G. Cho, J. Ramer, P. Rivailler, C. Quink, R. L. Garber, D. R. Beier, and F. Wang An Epstein-Barr-related herpesvirus from marmoset lymphomas PNAS, January 30, 2001; 98(3): 1224 - 1229. [Abstract] [Full Text] [PDF]

				S. W. Wong, E. P. Bergquam, R. M. Swanson, F. W. Lee, S. M. Shiigi, N. A. Avery, J. W. Fanton, and M. K. Axthelm Induction of B Cell Hyperplasia in Simian Immunodeficiency Virus–infected Rhesus Macaques with the Simian Homologue of Kaposi's Sarcoma–associated Herpesvirus J. Exp. Med., September 20, 1999; 190(6): 827 - 840. [Abstract] [Full Text] [PDF]

				E. Castanos-Velez, T. Heiden, M. Ekman, J. Lawrence, G. Biberfeld, and P. Biberfeld Proliferation and Apoptosis-Related Gene Expression in Experimental Acquired Immunodeficiency Syndrome-Related Simian Lymphoma Blood, February 15, 1999; 93(4): 1364 - 1371. [Abstract] [Full Text] [PDF]

				M. T. Maggiorella, F. Monardo, M. L. Koanga-Mogtomo, L. Cioe, L. Sernicola, F. Corrias, C. D. Baroni, P. Verani, and F. Titti Detection of Infectious Simian Immunodeficiency Virus in B- and T-Cell Lymphomas of Experimentally Infected Macaques Blood, May 1, 1998; 91(9): 3103 - 3111. [Abstract] [Full Text] [PDF]

				A. Moghaddam, J. Koch, B. Annis, and F. Wang Infection of Human B Lymphocytes with Lymphocryptoviruses Related to Epstein-Barr Virus J. Virol., April 1, 1998; 72(4): 3205 - 3212. [Abstract] [Full Text] [PDF]

				J. A. Beatty, J. J. Callanan, A. Terry, O. Jarrett, and J. C. Neil Molecular and Immunophenotypical Characterization of a Feline Immunodeficiency Virus (FIV)-Associated Lymphoma: a Direct Role for FIV in B-Lymphocyte Transformation? J. Virol., January 1, 1998; 72(1): 767 - 771. [Abstract] [Full Text] [PDF]