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American Journal of Pathology, Vol 137, 1317-1322, Copyright © 1990 by American Society for Investigative Pathology

REGULAR ARTICLES

Detection of HTLV-I proviral sequences in CD30-positive large cell cutaneous T-cell lymphomas

I Anagnostopoulos, M Hummel, P Kaudewitz, H Herbst, O Braun-Falco and H Stein
Steglitz Medical Center, Free University of Berlin, Federal Republic of Germany.

To investigate the possibility that cutaneous T-cell lymphomas of large cell type may be associated with human T-cell leukemia/lymphoma virus type I infection in nonendemic regions, tissue samples from six cases of large cell cutaneous T-cell lymphoma and four cases of small cell cutaneous T-cell lymphoma were screened for the presence of integrated proviral human T-cell leukemia/lymphoma virus type I DNA. Combined use of Southern blot hybridization and enzymatic DNA amplification revealed human T-cell leukemia/lymphoma virus type I-specific sequences in all cases of large cell cutaneous T-cell lymphoma and in none of the cases of small cell cutaneous T-cell lymphoma. These results suggest that in nonendemic areas, a significant proportion of large cell cutaneous T- cell lymphoma cases are associated with human T-cell leukemia/lymphoma virus type I.


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Copyright © 1990 by the American Society for Investigative Pathology.