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American Journal of Pathology, Vol 138, 9-15, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization

L Xerri, J Hassoun, J Planche, V Guigou, JJ Grob, P Parc, D Birnbaum and O deLapeyriere
Laboratoire d'Anatomo-pathologie, Institut Paoli-Calmettes, U119 INSERM, Marseille, France.

Biopsy samples from five acquired immune deficiency syndrome (AIDS)- Kaposi's sarcomas and one non-AIDS-associated Kaposi's sarcoma were assayed by in situ RNA hybridization onto paraformaldehyde-fixed, paraffin-embedded skin sections for the presence of two fibroblast growth factor gene transcripts, FGFB and FGF5. FGF5 gene expression was detected in the characteristic Kaposi's sarcoma spindle-shaped cells in the five samples from human immunodeficiency-positive (HIV+) patients. FGFB transcripts were detected in Kaposi's sarcoma cells as well as in epidermis of HIV- and HIV+ patients. These results complement the observations about growth factor gene expression done on Kaposi's sarcoma-derived cell lines, which thus appear to be representative of what happens in vivo. Furthermore, they demonstrate a contrasting expression pattern of FGF5 and FGFB genes, both involved in the growth factor pathogenic cascade leading to Kaposi's sarcoma.


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Copyright © 1991 by the American Society for Investigative Pathology.