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American Journal of Pathology, Vol 138, 515-520, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Ovarian granulosa-stromal cell tumors are characterized by trisomy 12

JA Fletcher, Z Gibas, K Donovan, A Perez-Atayde, D Genest, CC Morton and JM Lage
Department of Pathology, Brigham and Women's Hospital MA 02115.

Eleven ovarian granulosa-stromal cell tumors including 1 thecoma, 2 fibromas, 6 fibrothecomas, and 2 granulosa cell tumors, were karyotyped after direct harvest and/or short-term tissue culture. Bilateral fibrothecomas from one patient appeared to lack cytogenetic aberrations: the remaining nine tumors were characterized by trisomy for chromosome 12. Cytogenetic aberrations in the two granulosa cell tumors were much less complex than those described previously in undifferentiated carcinomas; accordingly cytogenetic analyses might be useful in distinguishing these categories. The consistent occurrence of trisomy 12 in different varieties of granulosa-stromal cell tumors suggests a common mechanism of oncogenesis within this diverse group of neoplasms. That mechanism probably involves promotion of low-grade, orderly cell proliferation.


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Copyright © 1991 by the American Society for Investigative Pathology.