| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 138, 521-524, Copyright © 1991 by American Society for Investigative Pathology
REGULAR ARTICLES |
TR Ulich, SM Yin, KZ Guo, J del Castillo, SP Eisenberg and RC Thompson
Department of Pathology, University of California Irvine 92717.
Endotoxin, a lipopolysaccharide (LPS) component of gram-negative bacteria, induces alveolar macrophages to express interleukin-1 (IL-1). Lipopolysaccharide and IL-1 both cause severe acute neutrophilic inflammation in the lung after intratracheal injection, suggesting that LPS-induced IL-1 expression contributes to the pathogenesis of LPS- induced acute inflammation. In the present study, the role of IL-1 in LPS-induced acute pneumonia was investigated by quantitating the acute inflammation occurring at 6 hours after the intratracheal injection of LPS as compared to the same timepoint after the intratracheal coinjection of LPS and IL-1 receptor antagonist (IL-1ra). The IL-1ra was found to inhibit LPS-induced acute inflammation (P greater than 0.0001) as measured by the number of neutrophils recovered in bronchoalveolar lavage. The LPS-induced emigration of neutrophils was inhibited by as much as 45%. Recombinant IL-1 beta-induced neutrophil emigration into the lung was inhibited by 95% when IL-1ra was coinjected intratracheally with IL-1 beta. Coinjection of recombinant IL-1 beta and LPS increased the neutrophilic exodus as compared to the intratracheal injection of either agent alone. Intratracheal injection of LPS induces a progressive increase in IL-1ra mRNA expression in whole-lung RNA preparations, suggesting that endogenous IL-1ra may play an important role as a negative feedback mechanism to downregulate LPS initiated IL-1-mediated acute inflammation. In conclusion IL-1ra inhibits both LPS- and IL-1-induced neutrophilic inflammation and may therefore prove clinically useful as an anti-inflammatory agent for the therapy of either septic or aseptic IL-1-mediated acute inflammation.
This article has been cited by other articles:
 |
|
 |
|
  S. Sethu, G. Mendez-Corao, and A. J. Melendez Phospholipase D1 Plays a Key Role in TNF-{alpha} Signaling J. Immunol., May 1, 2008; 180(9): 6027 - 6034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Itoh, H. Obata, S. Murakami, K. Hamada, K. Kangawa, H. Kimura, and N. Nagaya Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L446 - L452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Spight, B. Zhao, M. Haas, S. Wert, A. Denenberg, and T. P. Shanley Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L251 - L265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanabe, T. Matsumoto, K. Shibuya, K. Tateda, S. Miyazaki, A. Nakane, Y. Iwakura, and K. Yamaguchi Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae J. Med. Microbiol., January 1, 2005; 54(1): 7 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ferretti, O. Bonneau, G. R. Dubois, C. E. Jones, and A. Trifilieff IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger J. Immunol., February 15, 2003; 170(4): 2106 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Leemans, M. J. B. M. Vervoordeldonk, S. Florquin, K. P. van Kessel, and T. van der Poll Differential Role of Interleukin-6 in Lung Inflammation Induced by Lipoteichoic Acid and Peptidoglycan from Staphylococcus aureus Am. J. Respir. Crit. Care Med., May 15, 2002; 165(10): 1445 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takano, R. Yanagisawa, T. Ichinose, K. Sadakane, S. Yoshino, T. Yoshikawa, and M. Morita Diesel Exhaust Particles Enhance Lung Injury Related to Bacterial Endotoxin through Expression of Proinflammatory Cytokines, Chemokines, and Intercellular Adhesion Molecule-1 Am. J. Respir. Crit. Care Med., May 1, 2002; 165(9): 1329 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Willet, B. W. Kramer, S. G. Kallapur, M. Ikegami, J. P. Newnham, T. J. Moss, P. D. Sly, and A. H. Jobe Pre- and Postnatal Lung Development, Maturation, and Plasticity: Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L411 - L420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Rijneveld, S. Florquin, J. Branger, P. Speelman, S. J. H. Van Deventer, and T. van der Poll TNF-{alpha} Compensates for the Impaired Host Defense of IL-1 Type I Receptor-Deficient Mice During Pneumococcal Pneumonia J. Immunol., November 1, 2001; 167(9): 5240 - 5246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Manimtim, J. D. Hasday, L. Hester, K. D. Fairchild, J. C. Lovchik, and R. M. Viscardi Ureaplasma urealyticum Modulates Endotoxin-Induced Cytokine Release by Human Monocytes Derived from Preterm and Term Newborns and Adults Infect. Immun., June 1, 2001; 69(6): 3906 - 3915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Moreland, R. M. Fuhrman, C. L. Wohlford-Lenane, T. J. Quinn, E. Benda, J. A. Pruessner, and D. A. Schwartz TNF-{alpha} and IL-1{beta} are not essential to the inflammatory response in LPS-induced airway disease Am J Physiol Lung Cell Mol Physiol, January 1, 2001; 280(1): L173 - L180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. GIRAUD, P.-F. SEINCE, C. ROLLAND, V. LEÇON-MALAS, J.-M. DESMONTS, M. AUBIER, and M. DEHOUX Halothane Reduces the Early Lipopolysaccharide-induced Lung Inflammation in Mechanically Ventilated Rats Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2278 - 2286. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Moxley, T. L. Baird, and J. A. Corbett Adoptive transfer of acute lung injury Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L985 - L993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. P. JUFFERMANS, A. VERBON, J. T. BELISLE, P. J. HILL, P. SPEELMAN, S. J. H. van DEVENTER, and T. van der POLL Mycobacterial Lipoarabinomannan Induces an Inflammatory Response in the Mouse Lung . A Role for Interleukin-1 Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 486 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Blackwell, L. H. Lancaster, T. R. Blackwell, A. Venkatakrishnan, and J. W. Christman Differential NF-kappa B activation after intratracheal endotoxin Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L823 - L830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Strieter, S. L. Kunkel, M. P. Keane, and T. J. Standiford Chemokines in Lung Injury: Thomas A. Neff Lecture Chest, July 1, 1999; 116(2007): 103S - 110S. [Full Text]
|
|
|
|
|
|
L.-P. Wen, K. Madani, J. A. Fahrni, S. R. Duncan, and G. D. Rosen Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas Am J Physiol Lung Cell Mol Physiol, November 1, 1997; 273(5): L921 - L929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Beck-Schimmer, R. C. Schimmer, R. L. Warner, H. Schmal, G. Nordblom, C. M. Flory, M. E. Lesch, H. P. Friedl, D. J. Schrier, and P. A. Ward Expression of Lung Vascular and Airway ICAM-1 after Exposure to Bacterial Lipopolysaccharide Am. J. Respir. Cell Mol. Biol., September 1, 1997; 17(3): 344 - 352. [Abstract] [Full Text]
|
|
|
|
 |
|
 X.-Y. Hua, P. Chen, A. Fox, and R. R. Myers Involvement of Cytokines in Lipopolysaccharide-Induced Facilitation of CGRP Release from Capsaicin-Sensitive Nerves in the Trachea: Studies with Interleukin-1beta and Tumor Necrosis Factor-alpha J. Neurosci., August 1, 1996; 16(15): 4742 - 4748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Schultz, A. W. Rijneveld, S. Florquin, C. K. Edwards, C. A. Dinarello, and T. van der Poll Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia Am J Physiol Lung Cell Mol Physiol, February 1, 2002; 282(2): L285 - L290. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
