help button home button Am J Pathol PCR Enhanced. PCRboost from Biomatrica
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamaguchi, H.
Right arrow Articles by Hirai, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamaguchi, H.
Right arrow Articles by Hirai, S.

American Journal of Pathology, Vol 138, 699-705, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia

H Yamaguchi, Y Nakazato, M Shoji, K Okamoto, Y Ihara, M Morimatsu and S Hirai
College of Medical Care and Technology, Gunma University, Tokyo, Japan.

The hippocampal areas of 34 autopsy specimen brains from aged demented and nondemented subjects were examined using double staining of Bodian and beta protein. In 18 cases (75.5 +/- 7.4 years old), none of the extracellular neurofibrillary tangles (E-NFTs) were immunoreactive with beta protein. In 16 cases (82.9 +/- 5.4 years old), the minority of E- NFTs were immunoreactive with beta-protein antiserum. These beta- immunoreactive E-NFTs frequently appeared in the areas having senile plaques, while they were not observed in the area lacking beta- immunoreactive senile plaques. The ultrastructure of beta- immunoreactive E-NFTs revealed that they consisted of extracellular amyloid fibrils, extracellularly located bundles of paired helical filaments, astroglial processes and degenerating neurites. These findings suggest that the beta immunoreactivity of E-NFTs comes from secondary deposition of amyloid fibrils.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
J. L. Holton, J. Ghiso, T. Lashley, A. Rostagno, C. J. Guerin, G. Gibb, H. Houlden, H. Ayling, L. Martinian, B. H. Anderton, et al.
Regional Distribution of Amyloid-Bri Deposition and Its Association with Neurofibrillary Degeneration in Familial British Dementia
Am. J. Pathol., February 1, 2001; 158(2): 515 - 526.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Society for Investigative Pathology.