This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Traystman, M. D. Articles by Beisel, K. W. Search for Related Content PubMed PubMed Citation Articles by Traystman, M. D. Articles by Beisel, K. W.

American Journal of Pathology, Vol 138, 721-726, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14

MD Traystman, LH Chow, BM McManus, A Herskowitz, MN Nesbitt and KW Beisel
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495.

This study was undertaken to determine the genetic control of host susceptibility to coxsackievirus B3 (CVB3)-induced chronic myocarditis in a mouse model. An autosomal recessive autoimmune myocardial disease (amd) gene (possibly more than one gene), which determined susceptibility to CVB3-induced chronic myocarditis in the A/J and DBA/2J inbred mouse strains, was mapped to a segment of chromosome 14. Data from both the AXB/BXA recombinant inbred (RI) strains and the B10.D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcr alpha, and Myhc alpha loci.