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American Journal of Pathology, Vol 138, 1027-1033, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

The systemic distribution of Epstein-Barr virus genomes in fatal post- transplantation lymphoproliferative disorders. An in situ hybridization study

PS Randhawa, R Jaffe, AJ Demetris, M Nalesnik, TE Starzl, YY Chen and LM Weiss
Department of Pathology, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213.

The systemic distribution of Epstein-Barr virus (EBV) genomes was studied in paraffin-embedded tissues from 12 fatal cases of Post- transplantation lymphoproliferative disease (PTLD), using an in situ hybridization technique employing an alpha-35S-dCTP-radiolabeled BamHI- W fragment of EBV DNA. The presence of EBV was documented in various PTLD-involved organs. The hybridization signal for the virus localized predominantly in the abnormal lymphoid cells, but signals also were detected in hepatocytes and/or adrenal cortical cells in five cases. The distribution of autoradiographic label within the lymphoid cells was focal and its intensity varied from field to field suggesting a nonuniformity of the viral genomic load in the infected tissues. Recruitment of EBV genome-bearing cells was not observed into inflammatory mononuclear infiltrates found in organs without histopathologic evidence of PTLD.


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Copyright © 1991 by the American Society for Investigative Pathology.