| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 138, 951-960, Copyright © 1991 by American Society for Investigative Pathology
REGULAR ARTICLES |
CF Moyer, D Sajuthi, H Tulli and JK Williams
Department of Comparative Medicine, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
Interleukin-1 (IL-1) has been implicated as a regulatory protein in the development and clinical sequelae of atherosclerosis. To determine which cells in the atherosclerotic plaque synthesize IL-1 in situ, the authors evaluated histologic sections of iliac arteries from cynomolgus monkeys using probes for IL-1 alpha and beta. A polyclonal antibody to IL-1 alpha and beta was used to determine if proteins were concomitantly produced. The predominant cells expressing IL-1 alpha and beta mRNA were foam cells in the intima. Adherent leukocytes and vascular smooth muscle cells (VSMCs) expressed mRNA for IL-1 alpha. Microvascular endothelium expressed mRNA for both IL-1 alpha and beta. IL-1 proteins were located frequently in cells expressing IL-1 mRNA. These results indicate that endothelium and VSMCs, in conjunction with macrophages, serve as localized sources of IL-1 protein synthesis. These findings suggest that vascular cells may contribute directly to the pathogenesis of atherosclerotic vascular disease by actively secreting potent biologic mediators that modify vascular and immune cell function.
This article has been cited by other articles:
 |
|
 |
|
  H. Loppnow, K. Werdan, and M. Buerke Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms Innate Immunity, April 1, 2008; 14(2): 63 - 87. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Schultz, V. Murthy, J. B. Tatro, and D. Beasley Endogenous interleukin-1{alpha} promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2927 - H2934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Ma, X. Z. Ruan, S. H. Powis, J. F. Moorhead, and Z. Varghese Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2721 - H2728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Billiet, C. Furman, G. Larigauderie, C. Copin, K. Brand, J.-C. Fruchart, and M. Rouis Extracellular Human Thioredoxin-1 Inhibits Lipopolysaccharide-induced Interleukin-1{beta} Expression in Human Monocyte-derived Macrophages J. Biol. Chem., December 2, 2005; 280(48): 40310 - 40318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S G Baidya and Q-T Zeng Helper T cells and atherosclerosis: the cytokine web Postgrad. Med. J., December 1, 2005; 81(962): 746 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. W. Raines and N. Ferri Thematic Review Series: The Immune System and Atherogenesis. Cytokines affecting endothelial and smooth muscle cells in vascular disease J. Lipid Res., June 1, 2005; 46(6): 1081 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Chen, M. Sakuma, A. C. Zago, X. Zhang, C. Shi, L. Leng, Y. Mizue, R. Bucala, and D. I. Simon Evidence for a Role of Macrophage Migration Inhibitory Factor in Vascular Disease Arterioscler. Thromb. Vasc. Biol., April 1, 2004; 24(4): 709 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Monaco and E. Paleolog Nuclear factor {kappa}B: a potential therapeutic target in atherosclerosis and thrombosis Cardiovasc Res, March 1, 2004; 61(4): 671 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Von der Thusen, J. Kuiper, T. J. C. Van Berkel, and E. A. L. Biessen Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential Pharmacol. Rev., March 1, 2003; 55(1): 133 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Sukhova, J. K. Williams, and P. Libby Statins Reduce Inflammation in Atheroma of Nonhuman Primates Independent of Effects on Serum Cholesterol Arterioscler. Thromb. Vasc. Biol., September 1, 2002; 22(9): 1452 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Luft, M. Jefford, P. Luetjens, H. Hochrein, K.-A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky IL-1{beta} Enhances CD40 Ligand-Mediated Cytokine Secretion by Human Dendritic Cells (DC): A Mechanism for T Cell-Independent DC Activation J. Immunol., January 15, 2002; 168(2): 713 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Namiki, S. Kawashima, T. Yamashita, M. Ozaki, T. Hirase, T. Ishida, N. Inoue, K.-i. Hirata, A. Matsukawa, R. Morishita, et al. Local Overexpression of Monocyte Chemoattractant Protein-1 at Vessel Wall Induces Infiltration of Macrophages and Formation of Atherosclerotic Lesion: Synergism With Hypercholesterolemia Arterioscler. Thromb. Vasc. Biol., January 1, 2002; 22(1): 115 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Anderson, N. J. Boerth, M. Liu, D. B. McNamara, T. L. Cornwell, and T. M. Lincoln Cyclic GMP-Dependent Protein Kinase Expression in Coronary Arterial Smooth Muscle in Response to Balloon Catheter Injury Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2192 - 2197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Eriksson, J. Werr, Y. Guo, P. Thoren, and L. Lindbom Direct Observations In Vivo on the Role of Endothelial Selectins and {alpha}4 Integrin in Cytokine-Induced Leukocyte-Endothelium Interactions in the Mouse Aorta Circ. Res., March 17, 2000; 86(5): 526 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. FOSTER, P. WIESEL, G. S. HUGGINS, R. PAÑARES, M. T. CHIN, A. PELLACANI, and M. A. PERRELLA Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1{beta} in vascular smooth muscle cells FASEB J, February 1, 2000; 14(2): 368 - 378. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Uehara, H. Urata, M. Sasaguri, M. Ideishi, N. Sakata, T. Tashiro, M. Kimura, and K. Arakawa Increased Chymase Activity in Internal Thoracic Artery of Patients With Hypercholesterolemia Hypertension, January 1, 2000; 35(1): 55 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. de Frutos, L. S. de Miguel, M. Garcia-Duran, F. Gonzalez-Fernandez, J. A. Rodriguez-Feo, M. Monton, J. Guerra, J. Farre, S. Casado, and A. Lopez-Farre NO from smooth muscle cells decreases NOS expression in endothelial cells: role of TNF-alpha Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1317 - H1325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chamberlain, J. Gunn, S. Francis, C. Holt, and D. Crossman Temporal and spatial distribution of interleukin-1{beta} in balloon injured porcine coronary arteries Cardiovasc Res, October 1, 1999; 44(1): 156 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.L Mehta and D.Y Li Inflammation in ischemic heart disease: Response to tissue injury or a pathogenetic villain? Cardiovasc Res, August 1, 1999; 43(2): 291 - 299. [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. O'Brien, C. Pineda, W. S. Chiu, R. Bowen, and M. A. Deeg Glycosylphosphatidylinositol-Specific Phospholipase D Is Expressed by Macrophages in Human Atherosclerosis and Colocalizes With Oxidation Epitopes Circulation, June 8, 1999; 99(22): 2876 - 2882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ihara, H. Urata, A. Kinoshita, J. Suzumiya, M. Sasaguri, M. Kikuchi, M. Ideishi, and K. Arakawa Increased Chymase-Dependent Angiotensin II Formation in Human Atherosclerotic Aorta Hypertension, June 1, 1999; 33(6): 1399 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Reckless, E. M. Rubin, J. B. Verstuyft, J. C. Metcalfe, and D. J. Grainger Monocyte Chemoattractant Protein-1 but Not Tumor Necrosis Factor-{alpha} Is Correlated With Monocyte Infiltration in Mouse Lipid Lesions Circulation, May 4, 1999; 99(17): 2310 - 2316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McCrohon, W. Jessup, D. J. Handelsman, and D. S. Celermajer Androgen Exposure Increases Human Monocyte Adhesion to Vascular Endothelium and Endothelial Cell Expression of Vascular Cell Adhesion Molecule-1 Circulation, May 4, 1999; 99(17): 2317 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hennig, P. Meerarani, M. Toborek, and C. J. McClain Antioxidant-Like Properties of Zinc in Activated Endothelial Cells J. Am. Coll. Nutr., April 1, 1999; 18(2): 152 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Beasley and A. L. Cooper Constitutive expression of interleukin-1alpha precursor promotes human vascular smooth muscle cell proliferation Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H901 - H912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Francis, N. J. Camp, R. M. Dewberry, J. Gunn, P. Syrris, N. D. Carter, S. Jeffery, J. C. Kaski, D. C. Cumberland, G. W. Duff, et al. Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease Circulation, February 23, 1999; 99(7): 861 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Totani, A. Cumashi, A. Piccoli, and R. Lorenzet Polymorphonuclear Leukocytes Induce PDGF Release From IL-1ß–Treated Endothelial Cells : Role of Adhesion Molecules and Serine Proteases Arterioscler. Thromb. Vasc. Biol., October 1, 1998; 18(10): 1534 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Schonbeck, F. Mach, and P. Libby Generation of Biologically Active IL-1{beta} by Matrix Metalloproteinases: A Novel Caspase-1-Independent Pathway of IL-1{beta} Processing J. Immunol., October 1, 1998; 161(7): 3340 - 3346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Foster, B. M. Arkonac, N. E. S. Sibinga, C. Shi, M. A. Perrella, and E. Haber Regulation of CD44 Gene Expression by the Proinflammatory Cytokine Interleukin-1beta in Vascular Smooth Muscle Cells J. Biol. Chem., August 7, 1998; 273(32): 20341 - 20346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okada, A. Matsumori, K. Ono, Y. Furukawa, T. Shioi, A. Iwasaki, K. Matsushima, and S. Sasayama Cyclic Stretch Upregulates Production of Interleukin-8 and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., June 1, 1998; 18(6): 894 - 901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Nicholson and D. P. Hajjar Herpesviruses in Atherosclerosis and Thrombosis : Etiologic Agents or Ubiquitous Bystanders? Arterioscler. Thromb. Vasc. Biol., March 1, 1998; 18(3): 339 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Schonbeck, F. Mach, G. K. Sukhova, C. Murphy, J.-Y. Bonnefoy, R. P. Fabunmi, and P. Libby Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes : A Role for CD40 Signaling in Plaque Rupture? Circ. Res., September 19, 1997; 81(3): 448 - 454. [Abstract] [Full Text]
|
|
|
|
|
|
P. Kessler, J. Bauersachs, R. Busse, and V. B. Schini-Kerth Inhibition of Inducible Nitric Oxide Synthase Restores Endothelium-Dependent Relaxations in Proinflammatory Mediator-Induced Blood Vessels Arterioscler. Thromb. Vasc. Biol., September 1, 1997; 17(9): 1746 - 1755. [Abstract] [Full Text]
|
|
|
|
|
|
U. Schonbeck, F. Mach, J.-Y. Bonnefoy, H. Loppnow, H.-D. Flad, and P. Libby Ligation of CD40 Activates Interleukin 1beta -converting Enzyme (Caspase-1) Activity in Vascular Smooth Muscle and Endothelial Cells and Promotes Elaboration of Active Interleukin 1beta J. Biol. Chem., August 1, 1997; 272(31): 19569 - 19574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sasamura, Y. Nakazato, T. Hayashida, Y. Kitamura, M. Hayashi, and T. Saruta Regulation of Vascular Type 1 Angiotensin Receptors by Cytokines Hypertension, July 1, 1997; 30(1): 35 - 41. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Adams, W. Jessup, D. Hailstones, and D. S. Celermajer L-Arginine Reduces Human Monocyte Adhesion to Vascular Endothelium and Endothelial Expression of Cell Adhesion Molecules Circulation, February 4, 1997; 95(3): 662 - 668. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Liu, L. M. Hulten, and O. Wiklund Macrophages Isolated From Human Atherosclerotic Plaques Produce IL-8, and Oxysterols May Have a Regulatory Function for IL-8 Production Arterioscler. Thromb. Vasc. Biol., February 1, 1997; 17(2): 317 - 323. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Endres, U. Laufs, H. Merz, and M. Kaps Focal Expression of Intercellular Adhesion Molecule-1 in the Human Carotid Bifurcation Stroke, January 1, 1997; 28(1): 77 - 82. [Abstract] [Full Text]
|
|
|
|
|
|
J. Galea, J. Armstrong, P. Gadsdon, H. Holden, S. E. Francis, and C. M. Holt Interleukin-1ß in Coronary Arteries of Patients With Ischemic Heart Disease Arterioscler. Thromb. Vasc. Biol., August 1, 1996; 16(8): 1000 - 1006. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kadokami, H. Shimokawa, Y. Fukumoto, A. Ito, T. Takayanagi, K. Egashira, and A. Takeshita Coronary Artery Spasm Does Not Depend on the Intracellular Calcium Store but Is Substantially Mediated by the Protein Kinase C–Mediated Pathway in a Swine Model With Interleukin-1ß In Vivo Circulation, July 15, 1996; 94(2): 190 - 196. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. van der Kooij, O. H. Morand, H. J. Kempen, and T. J.C. van Berkel Decrease in Scavenger Receptor Expression in Human Monocyte–Derived Macrophages Treated With Granulocyte Macrophage Colony-Stimulating Factor Arterioscler. Thromb. Vasc. Biol., January 1, 1996; 16(1): 106 - 114. [Abstract] [Full Text]
|
|
|
|
|
|
E. Lee, A. J. Grodzinsky, P. Libby, S. K. Clinton, M. W. Lark, and R. T. Lee Human Vascular Smooth Muscle Cell–Monocyte Interactions and Metalloproteinase Secretion in Culture Arterioscler. Thromb. Vasc. Biol., December 1, 1995; 15(12): 2284 - 2289. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Schwartz, D. deBlois, and E. R. M. O'Brien The Intima : Soil for Atherosclerosis and Restenosis Circ. Res., September 1, 1995; 77(3): 445 - 465. [Full Text]
|
|
|
|
|
|
P. Libby Molecular Bases of the Acute Coronary Syndromes Circulation, June 1, 1995; 91(11): 2844 - 2850. [Full Text]
|
|
|
|
|
|
M. R. Adams, J. K. Williams, and J. R. Kaplan Effects of Androgens on Coronary Artery Atherosclerosis and Atherosclerosis-Related Impairment of Vascular Responsiveness Arterioscler. Thromb. Vasc. Biol., May 1, 1995; 15(5): 562 - 570. [Abstract] [Full Text]
|
|
|
|
|
|
J. Li, M. A. Perrella, J.-C. Tsai, S.-F. Yet, C.-M. Hsieh, M. Yoshizumi, C. Patterson, W. O. Endege, F. Zhou, and M.-E. Lee Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1beta in Rat Aortic Smooth Muscle Cells J. Biol. Chem., January 6, 1995; 270(1): 308 - 312. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
