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American Journal of Pathology, Vol 138, 1315-1319, Copyright © 1991 by American Society for Investigative Pathology
REGULAR ARTICLES |
BJ Rollins and JS Pober
Division of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115.
The authors have demonstrated that human interleukin-4 (IL-4) induces increased expression of the mRNA encoding the monocyte-specific chemoattractant and activator, MCP-1/JE, in human endothelial cells (EC). In addition, treatment of ECs with IL-4 resulted in the synthesis and secretion of MCP-1/JE protein. While IL-4 did not significantly influence the induced expression of MCP-1/JE mRNA by interleukin-1 (IL- 1) or tumor necrosis factor, concomitant treatment with IL-4 and IL-1 caused more secretion of MCP-1/JE protein than either cytokine alone. These results suggest that EC-produced MCP-1/JE may mediate some of IL- 4's effects on monocyte physiology in vivo, including IL-4's anti-tumor properties.
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