| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 138, 1527-1534, Copyright © 1991 by American Society for Investigative Pathology
REGULAR ARTICLES |
J Lundy, A Schuss, D Stanick, ES McCormack, S Kramer and JM Sorvillo
Department of Pathology, Winthrop University Hospital, Mineola, New York.
The major objectives of this study were twofold: to determine 1) if growth factors or growth factor receptors were expressed similarly or differently in a clinically well-characterized group of breast cancer patients and 2) if these phenotypic characteristics were associated with any of the commonly used prognostic parameters. Formalin-fixed paraffin-embedded tumor tissue from 51 node-positive breast cancer patients were analyzed for the expression of neu, epidermal growth factor-receptor (EGF-R), and transforming growth factor alpha (TGF alpha) using immunoperoxidase staining. Positive membranous staining for neu was observed in 15 (29%) tumors. Over-expression of neu was observed in high-grade, estrogen-receptor-negative tumors (P less than 0.05). Epidermal growth factor receptor was expressed in 22 (43%) of the tumors analyzed and found to a greater degree in estrogen-receptor- negative and high-grade tumors (P less than 0.025). A significant correlation between neu and EGF-R expression was also noted. Tumors expressing membranous staining of neu had a greater than 70% chance of expressing EGF-R (P less than 0.01). Expression of TGF alpha was found in 68% of tumors and TGF alpha was detected in grade 1 and 2 tumor to a greater degree than EGF-R. The authors conclude that assaying tumors for these antigens may give additional phenotypic characteristics that can give further insight into the biology of breast cancer.
This article has been cited by other articles:
 |
|
 |
|
  M. P. Cleary, X. Hu, M. E. Grossmann, S. C. Juneja, S. Dogan, J. P. Grande, and N. J. Maihle Prevention of Mammary Tumorigenesis by Intermittent Caloric Restriction: Does Caloric Intake During Refeeding Modulate the Response? Experimental Biology and Medicine, January 1, 2007; 232(1): 70 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Cleary, M. K. Jacobson, F. C. Phillips, S. C. Getzin, J. P. Grande, and N. J. Maihle Weight-Cycling Decreases Incidence and Increases Latency of Mammary Tumors to a Greater Extent Than Does Chronic Caloric Restriction in Mouse Mammary Tumor Virus- Transforming Growth Factor-{alpha} Female Mice Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 836 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Suo, B. Risberg, M. G. Karlsson, K. Villman, E. Skovlund, and J. M. Nesland The Expression of EGFR Family Ligands in Breast Carcinomas International Journal of Surgical Pathology, April 1, 2002; 10(2): 91 - 99. [Abstract] [PDF]
|
|
|
|
 |
|
 B. R. Davies, A. M. Platt-Higgins, G. Schmidt, and P. S. Rudland Development of Hyperplasias, Preneoplasias, and Mammary Tumors in MMTV-c-erbB-2 and MMTV-TGF{alpha} Transgenic Rats Am. J. Pathol., July 1, 1999; 155(1): 303 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wiesen, P Young, Z Werb, and G. Cunha Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development Development, January 1, 1999; 126(2): 335 - 344. [Abstract] [PDF]
|
|
|
|
 |
|
 J. A. Schroeder, M. C. Thompson, M. M. Gardner, and S. J. Gendler Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland J. Biol. Chem., April 13, 2001; 276(16): 13057 - 13064. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
