| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 139, 327-335, Copyright © 1991 by American Society for Investigative Pathology
REGULAR ARTICLES |
HL Chen, YP Yang, XL Hu, KK Yelavarthi, JL Fishback and JS Hunt
Department of Pathology, University of Kansas Medical Center, Kansas City 66103.
Tumor necrosis factor alpha (TNF-alpha), a polypeptide that regulates cellular growth and modulates the synthesis of various cell surface and secreted molecules, has been identified in the pregnant uterus. To determine which specific cells transcribed and translated this gene, extraembryonic fetal tissues (placenta and membranes) and uterine tissue from early and late stages of gestation were analyzed for TNF- alpha mRNA by in situ hybridization using biotinylated antisense and sense TNF-alpha probes, and for immunoreactive TNF-alpha using two monoclonal antibodies. Tumor necrosis factor-alpha transcripts and protein were identified in both extraembryonic and maternal cells. In first-trimester placental villi, TNF-alpha mRNA was present in syncytiotrophoblast but was low to absent in cytotrophoblast and villous stromal cells. Decidual and epithelial cells in maternal tissues contained TNF-alpha transcripts. In term placentas, both syncytiotrophoblast and villous stromal cells contained TNF-alpha mRNA, and transcripts were present in maternal cells in the decidua adjacent to the extraplacental membranes. In both first-trimester and term tissues, coincident expression of TNF-alpha mRNA and immunoreactive TNF- alpha was demonstrated. The results of this study show that TNF-alpha is synthesized by cells in both extraembryonic membranes and maternal tissues during human gestation and that transcription in specific types of cells is influenced by gestational age. These observations are consistent with a major role for TNF-alpha in the dynamic developmental events of human pregnancy.
This article has been cited by other articles:
 |
|
 |
|
  G. Desoye and S. Hauguel-de Mouzon The Human Placenta in Gestational Diabetes Mellitus: The insulin and cytokine network Diabetes Care, July 1, 2007; 30(Supplement_2): S120 - S126. [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Straszewski-Chavez, I. P. Visintin, N. Karassina, G. Los, P. Liston, R. Halaban, A. Fadiel, and G. Mor XAF1 Mediates Tumor Necrosis Factor-{alpha}-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway J. Biol. Chem., April 27, 2007; 282(17): 13059 - 13072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lambin, R. van Bree,, I. Vergote, and J. Verhaeghe Chronic Tumor Necrosis Factor-{alpha} Infusion in Gravid C57BL6/J Mice Accelerates Adipose Tissue Development in Female Offspring Reproductive Sciences, December 1, 2006; 13(8): 558 - 565. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Cohen, A. Meisser, L. Haenggeli, and P. Bischof Involvement of MAPK pathway in TNF-{alpha}-induced MMP-9 expression in human trophoblastic cells Mol. Hum. Reprod., April 1, 2006; 12(4): 225 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nagira, T. Sasaoka, T. Wada, K. Fukui, M. Ikubo, S. Hori, H. Tsuneki, S. Saito, and M. Kobayashi Altered Subcellular Distribution of Estrogen Receptor {alpha} Is Implicated in Estradiol-Induced Dual Regulation of Insulin Signaling in 3T3-L1 Adipocytes Endocrinology, February 1, 2006; 147(2): 1020 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Straszewski-Chavez, V. M. Abrahams, and G. Mor The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy Endocr. Rev., December 1, 2005; 26(7): 877 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Verhaeghe, R. van Bree, S. Lambin, and S. Caluwaerts Adipokine Profile and C-Reactive Protein in Pregnancy: Effects of Glucose Challenge Response Versus Body Mass Index Reproductive Sciences, July 1, 2005; 12(5): 330 - 334. [Abstract] [PDF]
|
|
|
|
 |
|
 J. E. Caminos, R. Nogueiras, R. Gallego, S. Bravo, S. Tovar, T. Garcia-Caballero, F. F. Casanueva, and C. Dieguez Expression and Regulation of Adiponectin and Receptor in Human and Rat Placenta J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4276 - 4286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. D. LaMarca, K. Cockrell, E. Sullivan, W. Bennett, and J. P. Granger Role of Endothelin in Mediating Tumor Necrosis Factor-Induced Hypertension in Pregnant Rats Hypertension, July 1, 2005; 46(1): 82 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hunt, M. G. Petroff, R. H. McIntire, and C. Ober HLA-G and immune tolerance in pregnancy FASEB J, May 1, 2005; 19(7): 681 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-H. Hung, D. S. Charnock-Jones, J. N. Skepper, and G. J. Burton Secretion of Tumor Necrosis Factor-{alpha} from Human Placental Tissues Induced by Hypoxia-Reoxygenation Causes Endothelial Cell Activation in Vitro: A Potential Mediator of the Inflammatory Response in Preeclampsia Am. J. Pathol., March 1, 2004; 164(3): 1049 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bauer, J. Pollheimer, J. Hartmann, P. Husslein, J. D. Aplin, and M. Knofler Tumor Necrosis Factor-{alpha} Inhibits Trophoblast Migration through Elevation of Plasminogen Activator Inhibitor-1 in First-Trimester Villous Explant Cultures J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 812 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Morales, J. L. Pace, J. S. Platt, T. A. Phillips, K. Morgan, A. T. Fazleabas, and J. S. Hunt Placental Cell Expression of HLA-G2 Isoforms Is Limited to the Invasive Trophoblast Phenotype J. Immunol., December 1, 2003; 171(11): 6215 - 6224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ka and J. S. Hunt Temporal and Spatial Patterns of Expression of Inhibitors of Apoptosis in Human Placentas Am. J. Pathol., August 1, 2003; 163(2): 413 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Phillips, J. Ni, and J. S. Hunt Cell-specific expression of B lymphocyte (APRIL, BLyS)- and Th2 (CD30L/CD153)-promoting tumor necrosis factor superfamily ligands in human placentas J. Leukoc. Biol., July 1, 2003; 74(1): 81 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vidricaire, M. R. Tardif, and M. J. Tremblay The Low Viral Production in Trophoblastic Cells Is Due to a High Endocytic Internalization of the Human Immunodeficiency Virus Type 1 and Can Be Overcome by the Pro-inflammatory Cytokines Tumor Necrosis Factor-alpha and Interleukin-1 J. Biol. Chem., April 25, 2003; 278(18): 15832 - 15841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Gill, J. Ni, and J. S. Hunt Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes Am. J. Pathol., December 1, 2002; 161(6): 2011 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chan, D. G. Hemmings, A. D. Yurochko, and L. J. Guilbert Human Cytomegalovirus-Caused Damage to Placental Trophoblasts Mediated by Immediate-Early Gene-Induced Tumor Necrosis Factor-{alpha} Am. J. Pathol., October 1, 2002; 161(4): 1371 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Wira, M. A. Roche, and R. M. Rossoll Antigen Presentation by Vaginal Cells: Role of TGF{beta} as a Mediator of Estradiol Inhibition of Antigen Presentation Endocrinology, August 1, 2002; 143(8): 2872 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Kirwan, S. Hauguel-De Mouzon, J. Lepercq, J.-C. Challier, L. Huston-Presley, J. E. Friedman, S. C. Kalhan, and P. M. Catalano TNF-{alpha} Is a Predictor of Insulin Resistance in Human Pregnancy Diabetes, July 1, 2002; 51(7): 2207 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. A. Kayisli, B. Selam, R. Demir, and A. Arici Expression of vasodilator-stimulated phosphoprotein in human placenta: possible implications in trophoblast invasion Mol. Hum. Reprod., January 1, 2002; 8(1): 88 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Benyo, A. Smarason, C. W. G. Redman, C. Sims, and K. P. Conrad Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2505 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sato, H. Michizu, K. Hashizume, and A. Ito Hormonal regulation of PGE2 and COX-2 production in rabbit uterine cervical fibroblasts J Appl Physiol, April 1, 2001; 90(4): 1227 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Miyamoto, D. J. Skarzynski, and K. Okuda Is Tumor Necrosis Factor {alpha} a Trigger for the Initiation of Endometrial Prostaglandin F2{alpha} Release at Luteolysis in Cattle? Biol Reprod, May 1, 2000; 62(5): 1109 - 1115. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. A. Bowen and J. S. Hunt The Role of Integrins in Reproduction Experimental Biology and Medicine, April 1, 2000; 223(4): 331 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Phillips, J. Ni, G. Pan, S. M. Ruben, Y.-F. Wei, J. L. Pace, and J. S. Hunt TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilege J. Immunol., May 15, 1999; 162(10): 6053 - 6059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-S. Lee, M. K. Jain, B. M. Arkonac, D. Zhang, S.-Y. Shaw, S. Kashiki, K. Maemura, S.-L. Lee, N. K. Hollenberg, M.-E. Lee, et al. Thy-1, a Novel Marker for Angiogenesis Upregulated by Inflammatory Cytokines Circ. Res., May 4, 1998; 82(8): 845 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gorivodsky, I. Zemlyak, H. Orenstein, S. Savion, A. Fein, A. Torchinsky, and V. Toder TNF-{alpha} Messenger RNA and Protein Expression in the Uteroplacental Unit of Mice with Pregnancy Loss J. Immunol., May 1, 1998; 160(9): 4280 - 4288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fried, R. O. Muga, A. O. Misore, and P. E. Duffy Malaria Elicits Type 1 Cytokines in the Human Placenta: IFN-{gamma} and TNF-{alpha} Associated with Pregnancy Outcomes J. Immunol., March 1, 1998; 160(5): 2523 - 2530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Benyo, T. M. Miles, and K. P. Conrad Hypoxia Stimulates Cytokine Production by Villous Explants from the Human Placenta J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1582 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Catalano, S. E. Nizielski, J. Shao, L. Preston, L. Qiao, and J. E. Friedman Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E522 - E533. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
