help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McComb, R. D.
Right arrow Articles by Carson, S. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McComb, R. D.
Right arrow Articles by Carson, S. D.

American Journal of Pathology, Vol 139, 491-494, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Tissue factor antigen in senile plaques of Alzheimer's disease

RD McComb, KA Miller and SD Carson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495.

Tissue factor (tissue thromboplastin) is the primary initiator of the extrinsic coagulation pathway, triggering a proteolytic cascade when exposed to circulating coagulation factors. In this study, the distribution of tissue factor was examined immunohistochemically in Alzheimer's disease (AD) and control brains. Tissue factor was expressed diffusely in the neocortex, but in AD there was enhanced immunoreactivity in senile plaques. Although tissue factor might potentially contribute to the formation of senile plaques, it could also accumulate in the plaques as a secondary response to other biochemical perturbations.


This article has been cited by other articles:


Home page
 StrokeHome page
Y. Hirashima, S. Nakamura, M. Suzuki, M. Kurimoto, S. Endo, A. Ogawa, and A. Takaku
Cerebrospinal Fluid Tissue Factor and Thrombin-Antithrombin III Complex as Indicators of Tissue Injury After Subarachnoid Hemorrhage
Stroke, September 1, 1997; 28(9): 1666 - 1670.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Society for Investigative Pathology.