This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miyazono, M. Articles by Tateishi, J. Search for Related Content PubMed PubMed Citation Articles by Miyazono, M. Articles by Tateishi, J.

American Journal of Pathology, Vol 139, 589-598, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation

M Miyazono, T Iwaki, T Kitamoto, Y Kaneko, K Doh-ura and J Tateishi
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

The authors examined 10 patients with Gerstmann-Straussler syndrome or Creutzfeldt-Jakob disease and 10 with Alzheimer's disease (AD). Immunohistochemistry using anti-prion protein (PrP) and anti-beta/A4 protein (beta/A4) coupled with formic acid pretreatment could detect Congophilic and non-Congophilic deposits. Prion protein deposits were classified into five types and compared with types of beta/A4 deposits. Kuru plaques with multicentric cores and fine granular deposits were a characteristic feature of PrP deposits. Some types of PrP or beta/A4 deposits depend on the anatomic sites. To clarify the relationship of microglia and astrocytes to PrP or beta/A4 deposits, double- immunostaining method was performed. In both kuru and senile plaques, microglia were closely linked to the Congophilic plaques. Astrocytes, however, extended their processes toward the plaques even in the non- Congophilic plaques. These observations strongly suggest that similar glial association with plaque formation may be involved in both kuru and senile plaques, although the amyloid core proteins differ.

This article has been cited by other articles:

				J. Priller, M. Prinz, M. Heikenwalder, N. Zeller, P. Schwarz, F. L. Heppner, and A. Aguzzi Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie. J. Neurosci., November 8, 2006; 26(45): 11753 - 11762. [Abstract] [Full Text] [PDF]

				M. Marella, C. Gaggioli, M. Batoz, M. Deckert, S. Tartare-Deckert, and J. Chabry Pathological Prion Protein Exposure Switches on Neuronal Mitogen-activated Protein Kinase Pathway Resulting in Microglia Recruitment J. Biol. Chem., January 14, 2005; 280(2): 1529 - 1534. [Abstract] [Full Text] [PDF]

				L. Gan, S. Ye, A. Chu, K. Anton, S. Yi, V. A. Vincent, D. von Schack, D. Chin, J. Murray, S. Lohr, et al. Identification of Cathepsin B as a Mediator of Neuronal Death Induced by A{beta}-activated Microglial Cells Using a Functional Genomics Approach J. Biol. Chem., February 13, 2004; 279(7): 5565 - 5572. [Abstract] [Full Text] [PDF]

				O. Andreoletti, P. Berthon, E. Levavasseur, D. Marc, F. Lantier, E. Monks, J.-M. Elsen, and F. Schelcher Phenotyping of Protein-Prion (PrPsc)-accumulating Cells in Lymphoid and Neural Tissues of Naturally Scrapie-affected Sheep by Double-labeling Immunohistochemistry J. Histochem. Cytochem., October 1, 2002; 50(10): 1357 - 1370. [Abstract] [Full Text] [PDF]

				C. K. Combs, J. C. Karlo, S.-C. Kao, and G. E. Landreth {beta}-Amyloid Stimulation of Microglia and Monocytes Results in TNF{alpha}-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis J. Neurosci., February 15, 2001; 21(4): 1179 - 1188. [Abstract] [Full Text] [PDF]

				C. K. Combs, D. E. Johnson, S. B. Cannady, T. M. Lehman, and G. E. Landreth Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of beta -Amyloid and Prion Proteins J. Neurosci., February 1, 1999; 19(3): 928 - 939. [Abstract] [Full Text] [PDF]

				N. Y. Calingasan, L. C. H. Park, L. L. Calo, R. R. Trifiletti, S. E. Gandy, and G. E. Gibson Induction of Nitric Oxide Synthase and Microglial Responses Precede Selective Cell Death Induced by Chronic Impairment of Oxidative Metabolism Am. J. Pathol., August 1, 1998; 153(2): 599 - 610. [Abstract] [Full Text] [PDF]

				T. Uchihara, H. Akiyama, H. Kondo, and K. Ikeda Activated Microglial Cells Are Colocalized With Perivascular Deposits of Amyloid-{beta} Protein in Alzheimer's Disease Brain Stroke, October 1, 1997; 28(10): 1948 - 1950. [Abstract] [Full Text]