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American Journal of Pathology, Vol 139, 737-742, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Aberrant accumulation of phospholipase C-delta in Alzheimer brains

S Shimohama, Y Homma, T Suenaga, S Fujimoto, T Taniguchi, W Araki, Y Yamaoka, T Takenawa and J Kimura
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

Since phosphoinositide-specific phospholipase C (PLC) is one of the key molecules in signal transduction, the authors assessed its involvement in Alzheimer's disease (AD). Immunostaining of a specific antibody against the PLC isozyme, PLC-delta, demonstrated that this enzyme was abnormally accumulated in neurofibrillary tangles (NFT), the neurites surrounding senile plaque (SP) cores, and neuropil threads in AD brains. Western blot analysis confirmed that PLC-delta was concentrated in the paired helical filament (PHF)-rich fraction of AD brains. Antibodies to other PLC isozymes did not produce positive immunostaining of these pathologic structures. Moreover, diffuse and amorphous deposits of PLC-delta were found to precede the accumulation of fibrillary deposits. These results suggest that PLC-delta accumulation is a crucial event that ultimately may contribute to the formation of PHF.


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Copyright © 1991 by the American Society for Investigative Pathology.