help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Connell, K.
Right arrow Articles by Edidin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Connell, K.
Right arrow Articles by Edidin, M.

American Journal of Pathology, Vol 139, 743-749, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Endothelial cells transformed by SV40 T antigen cause Kaposi's sarcomalike tumors in nude mice

K O'Connell, G Landman, E Farmer and M Edidin
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Injection into nude mice of a well-differentiated SV40 T-antigen- transformed murine endothelial cell (EC) line results in widespread invasive tumors confined to connective tissues. The tumors, which do not metastasize, consist of both host-derived cells and transformed EC, displaying histologic features typical of Kaposi's sarcoma (KS). Although the EC is believed to be the cell of origin in KS, this has not been proven and is the subject of debate. The unusual tumorigenicity of this transformed cell suggests that EC-specific gene products induced by SV40 T antigen may contribute to tumorigenesis by autocrine growth stimulation and recruitment of host cells. KS-like tumors may be the result of EC alteration by any virus that induces relevant EC-derived cytokines.


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
J. Walter-Yohrling, S. Morgenbesser, C. Rouleau, R. Bagley, M. Callahan, W. Weber, and B. A. Teicher
Murine Endothelial Cell Lines as Models of Tumor Endothelial Cells
Clin. Cancer Res., March 15, 2004; 10(6): 2179 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Corallini, L. Possati, C. Trabanelli, E. Giraudo, R. Rocchetti, S. Talevi, A. Caputo, F. Bussolino, and G. Barbanti-Brodano
Tumor-host interaction mediates the regression of BK virus-induced vascular tumors in mice: involvement of transforming growth factor-{beta}1
Carcinogenesis, September 1, 2003; 24(9): 1435 - 1444.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Society for Investigative Pathology.