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American Journal of Pathology, Vol 139, 933-938, Copyright © 1991 by American Society for Investigative Pathology

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Rosenthal fibers contain ubiquitinated alpha B-crystallin

JE Goldman and E Corbin
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032.

The vertebrate lens protein, alpha B-crystallin, is a major component of Rosenthal fibers (RFs) inclusion in astrocytes in Alexander's disease. Antibodies to ubiquitin bind to RFs, but it is not known whether the ubiquitin associated with RFs is bound to a specific protein or proteins, and if so, what the identity of the conjugates is. The authors have analyzed the proteins of RFs from Alexander's disease and have found mono- and polyubiquitinated conjugates of alpha B- crystallin.

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