help button home button Am J Pathol ASIP MEMBERSHIP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rao, M. S.
Right arrow Articles by Reddy, J. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rao, M. S.
Right arrow Articles by Reddy, J. K.

American Journal of Pathology, Vol 139, 1111-1117, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Alterations of pancreatic hepatocytes in rats exposed to carcinogens

MS Rao, V Subbarao, K Sato and JK Reddy
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611.

In this study, acute and chronic responses of pancreatic hepatocytes induced in F-344 rats by copper depletion-repletion protocol to certain hepatocarcinogens were examined. Administration of a single dose of tannic acid (subcutaneous), aflatoxin B1 (gavage), or lasiocarpine (intraperitoneally) caused characteristic nucleolar segregation in parenchymal cells of liver as well as in pancreatic hepatocytes. Chronic dietary administration of 2-acetylaminofluorene (0.025%) for 12 to 32 weeks led to the development of glutathione S-transferase-P- positive pancreatic hepatocytes in the pancreas. In addition, oval cell proliferation was observed in close association with pancreatic hepatocytes, but not in other areas of pancreas containing residual acinar cells. Oval cells in the pancreas and in the liver that developed in rats after chronic 2-acetylaminofluorene treatment and pancreatic duct cells stained positively with rat liver oval cell marker OV-6 antibodies by immunoperoxidase. These findings indicate that pancreatic hepatocytes respond to carcinogens in a fashion similar to parenchymal cells of liver.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
S. Paku, J. Schnur, P. Nagy, and S. S. Thorgeirsson
Origin and Structural Evolution of the Early Proliferating Oval Cells in Rat Liver
Am. J. Pathol., April 1, 2001; 158(4): 1313 - 1323.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Society for Investigative Pathology.