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American Journal of Pathology, Vol 139, 1267-1271, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Myositis in mice inoculated with Borrelia burgdorferi

C Museteanu, UE Schaible, T Stehle, MD Kramer and MM Simon
Max-Planck-Institut fur Immunbiologie, Freiburg, Federal Republic of Germany.

The authors describe the appearance of myositis in immunocompetent and immunodeficient mice after subcutaneous inoculation with Borrelia burgdorferi by histology and immunohistology. Experimental infection of mice 1) causes inflammation of striated but not smooth muscles, 2) affects the entire musculoskeletal system, and 3) is characterized by perivascular and interfacicular infiltration of mononuclear leukocytes in the striated muscle leading to necrosis as well as disruption of muscle fibers. The lesions found in striated muscle specimens were most pronounced in immunodeficient (SCID), less severe in T-cell-deficient nu/nu (BALB/c, C57BL/6) and marginal to moderate or almost not present in immunocompetent AKR/N and C.B-17 mice, respectively.


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Copyright © 1991 by the American Society for Investigative Pathology.