help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Micklem, K. J.
Right arrow Articles by Mason, D. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Micklem, K. J.
Right arrow Articles by Mason, D. Y.

American Journal of Pathology, Vol 139, 1297-1301, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit

KJ Micklem, Y Dong, A Willis, KA Pulford, L Visser, H Durkop, S Poppema, H Stein and DY Mason
Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Pathology, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

The monoclonal antibodies HML-1, B-ly7 and Ber-ACT8 recognize intramucosal gut T lymphocytes, activated cells, and hairy cell leukemia. The antigen on hairy cells consists of three glycoproteins (160 kappa D, 130 kappa D and 105 kappa D unreduced; 145 kappa D and 120 kappa D reduced). These peptides have biochemical features reminiscent of integrins but we have shown by immunoprecipitation that they are not known integrin subunits. We have used a newly produced antibody (BP6) to purify this molecule and shown by N-terminal sequence analysis that the smallest subunit is the product of integrin beta 7 cDNA. This molecule is thus a new member of the integrin family of leucocyte adhesion proteins. Immunoprecipitation experiments indicate that the two larger subunits are recognized by HML-1, B-ly7 and Ber- ACT8.


This article has been cited by other articles:


Home page
 BloodHome page
F. Forconi, S. S. Sahota, D. Raspadori, C. I. Mockridge, F. Lauria, and F. K. Stevenson
Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing
Blood, August 15, 2001; 98(4): 1174 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. D. Jennings and K. A. Foon
Recent Advances in Flow Cytometry: Application to the Diagnosis of Hematologic Malignancy
Blood, October 15, 1997; 90(8): 2863 - 2892.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. G. Higgins, M. Cernadas, K. Tan, A. Irie, J.-h. Wang, Y. Takada, and M. B. Brenner
The Role of alpha and beta Chains in Ligand Recognition by beta 7 Integrins
J. Biol. Chem., August 11, 2000; 275(33): 25652 - 25664.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American Society for Investigative Pathology.