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American Journal of Pathology, Vol 139, 1303-1308, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis

T Iwaki and J Tateishi
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of alpha B- crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of alpha B-crystallin in the hamartomas in conjunction with the alpha B-crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of alpha B-crystallin gene expression.


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Copyright © 1991 by the American Society for Investigative Pathology.