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American Journal of Pathology, Vol 139, 1463-1470, Copyright © 1991 by American Society for Investigative Pathology

REGULAR ARTICLES

The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments

A Crowe, H Ksiezak-Reding, WK Liu, DW Dickson and SH Yen
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461.

Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species- specific amino acid sequences.


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Copyright © 1991 by the American Society for Investigative Pathology.