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American Journal of Pathology, Vol 140, 1-8, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells

DW Bahler, G Berry, J Oksenberg, RA Warnke and R Levy
Department of Medicine, Stanford University Medical Center, California.

The expression of T-cell antigen receptor beta-chain variable genes (V beta) was evaluated in 28 cases of mycosis fungoides. A novel polymerase chain reaction (PCR) technique was used to associate expression of particular V beta genes with monoclonal T-cell populations. In addition, the same biopsies used for PCR analysis were also examined for reactivity with a panel of seven monoclonal antibodies that specifically recognized V beta proteins from four different families. Only three cases clearly stained with the antibodies, a result consistent with a diverse set of V beta genes being used. This was confirmed by PCR analysis, which indicated that V beta genes from many different families were expressed by these tumors. Preferential use of the V beta 8 family, which had been previously use of the V beta 8 family, which had been previously reported for this disease, was not evident among the cases analyzed.

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