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American Journal of Pathology, Vol 140, 109-118, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Keratin expression in chemically induced mouse lung adenomas

WT Gunning, PJ Goldblatt and GD Stoner
Department of Pathology, Medical College of Ohio, Toledo 43699-0008.

Chemically induced mouse lung tumors exhibit distinctive growth patterns, characterized by an alveolar or solid appearance, a papillary appearance, or a combination of the two. Lung tumors induced in strain A/J mice by either benzo(a)pyrene (BP) or by N-nitrosoethylurea (ENU) were examined for expression of low- and high-molecular-weight cytokeratins. Simple cytokeratins (low molecular weight) were found in all epithelial cells of the normal mouse lung and in all tumor types, whereas higher-molecular-weight cytokeratins were found only in normal bronchiolar cells and in papillary tumor cells. These data lend support to the hypothesis that chemically induced papillary lung tumors in strain A/J mice are derived from bronchiolar Clara cells.


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Copyright © 1992 by the American Society for Investigative Pathology.