This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Poston, R. N. Articles by Johnson-Tidey, R. R. Search for Related Content PubMed PubMed Citation Articles by Poston, R. N. Articles by Johnson-Tidey, R. R.

American Journal of Pathology, Vol 140, 665-673, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of intercellular adhesion molecule-1 in atherosclerotic plaques

RN Poston, DO Haskard, JR Coucher, NP Gall and RR Johnson-Tidey
Department of Experimental Pathology, United Medical and Dental School, Guy's Hospital, London, United Kingdom.

Immunohistochemistry of human atherosclerotic arteries demonstrates expression of the intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, macrophages, and smooth muscle cells of the plaques. Normal arterial endothelial cells and intimal smooth muscle outside plaques give weaker or negative reactions; these differ from the strong endothelial expression in small vessels. Quantitative color-image analysis of the endothelial layer shows increased expression of ICAM-1 in all subtypes of atherosclerotic lesions, except fibrous plaques. Endothelial expression of ICAM-1 may be involved in the recruitment of monocytes to the lesion, as suggested by its role in the entry of leukocytes, including monocytes, into foci of inflammation. Collaboration with other mechanisms, particularly chemoattractant factors, may be important for this effect. ICAM-1 enhanced monocyte recruitment is a potential mechanism for the growth of an atherosclerotic plaque.

This article has been cited by other articles:

				Y. Wang, X. Zhao, H. Jin, H. Wei, W. Li, D. Bu, X. Tang, Y. Ren, C. Tang, and J. Du Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice Arterioscler Thromb Vasc Biol, February 1, 2009; 29(2): 173 - 179. [Abstract] [Full Text] [PDF]

				J. M. Gitlin, J. W. Homeister, J. Bulgrien, J. Counselman, L. K. Curtiss, J. B. Lowe, and W. A. Boisvert Disruption of Tissue-Specific Fucosyltransferase VII, an Enzyme Necessary for Selectin Ligand Synthesis, Suppresses Atherosclerosis in Mice Am. J. Pathol., January 1, 2009; 174(1): 343 - 350. [Abstract] [Full Text] [PDF]

				H. Sato, R. Kato, Y. Isogai, G.-i. Saka, M. Ohtsuki, Y. Taketomi, K. Yamamoto, K. Tsutsumi, J. Yamada, S. Masuda, et al. Analyses of Group III Secreted Phospholipase A2 Transgenic Mice Reveal Potential Participation of This Enzyme in Plasma Lipoprotein Modification, Macrophage Foam Cell Formation, and Atherosclerosis J. Biol. Chem., November 28, 2008; 283(48): 33483 - 33497. [Abstract] [Full Text] [PDF]

				M. Khaleghi, Z. Ali, T. H. Mosley Jr., S. T. Turner, and I. J. Kullo Association of Soluble Cell Adhesion Molecules with Ankle-Brachial Index in a Biethnic Cohort of Predominantly Hypertensive Individuals Clin. Chem., November 1, 2008; 54(11): 1788 - 1795. [Abstract] [Full Text] [PDF]

				G. Zaza, P. Pontrelli, G. Pertosa, S. Granata, M. Rossini, S. Porreca, F. J. T. Staal, L. Gesualdo, G. Grandaliano, and F. P. Schena Dialysis-related systemic microinflammation is associated with specific genomic patterns Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1673 - 1681. [Abstract] [Full Text] [PDF]

				A. D. Pradhan, S. Shrivastava, N. R. Cook, N. Rifai, M. A. Creager, and P. M Ridker Symptomatic Peripheral Arterial Disease in Women: Nontraditional Biomarkers of Elevated Risk Circulation, February 12, 2008; 117(6): 823 - 831. [Abstract] [Full Text] [PDF]

				T. Ichiki, M. Jougasaki, M. Setoguchi, J. Imamura, H. Nakashima, T. Matsuoka, M. Sonoda, K. Nakamura, S. Minagoe, and C. Tei Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H750 - H763. [Abstract] [Full Text] [PDF]

				W.-J. Zhang, K. E. Bird, T. S. McMillen, R. C. LeBoeuf, T. M. Hagen, and B. Frei Dietary {alpha}-Lipoic Acid Supplementation Inhibits Atherosclerotic Lesion Development in Apolipoprotein E Deficient and Apolipoprotein E/Low-Density Lipoprotein Receptor Deficient Mice Circulation, January 22, 2008; 117(3): 421 - 428. [Abstract] [Full Text] [PDF]

				G. Stoll and M. Bendszus Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization Stroke, July 1, 2006; 37(7): 1923 - 1932. [Abstract] [Full Text] [PDF]

				J. S. Kang, Y. D. Yoon, M. H. Han, S.-B. Han, K. Lee, K. H. Lee, S.-K. Park, and H. M. Kim Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-{alpha}-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-{kappa}B/Rel Signaling Pathways Mol. Pharmacol., March 1, 2006; 69(3): 941 - 949. [Abstract] [Full Text] [PDF]

				C. S. Kim, S. J. Son, E. K. Kim, S. N. Kim, D. G. Yoo, H. S. Kim, S. W. Ryoo, S. D. Lee, K. Irani, and B. H. Jeon Apurinic/apyrimidinic endonuclease1/redox factor-1 inhibits monocyte adhesion in endothelial cells Cardiovasc Res, February 1, 2006; 69(2): 520 - 526. [Abstract] [Full Text] [PDF]

				O. Quehenberger Thematic Review Series: The Immune System and Atherogenesis. Molecular mechanisms regulating monocyte recruitment in atherosclerosis J. Lipid Res., August 1, 2005; 46(8): 1582 - 1590. [Abstract] [Full Text] [PDF]

				H. S. Markus, B. Hunt, K. Palmer, C. Enzinger, H. Schmidt, and R. Schmidt Markers of Endothelial and Hemostatic Activation and Progression of Cerebral White Matter Hyperintensities: Longitudinal Results of the Austrian Stroke Prevention Study Stroke, July 1, 2005; 36(7): 1410 - 1414. [Abstract] [Full Text] [PDF]

				T Sampietro, F Bigazzi, B D. Pino, G Rossi, E Chella, S Lusso, M Puntoni, M Tuoni, and A Bionda Up regulation of C3, C4, and soluble intercellular adhesion molecule-1 co-expresses with high sensitivity C reactive protein in familial hypoalphalipoproteinaemia: further evidence of inflammatory activation Heart, December 1, 2004; 90(12): 1438 - 1442. [Abstract] [Full Text] [PDF]

				R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]

				E. Zouridakis, P. Avanzas, R. Arroyo-Espliguero, S. Fredericks, and J. C. Kaski Markers of Inflammation and Rapid Coronary Artery Disease Progression in Patients With Stable Angina Pectoris Circulation, September 28, 2004; 110(13): 1747 - 1753. [Abstract] [Full Text] [PDF]

				S. Bro, F. Moeller, C. B. Andersen, K. Olgaard, and L. B. Nielsen Increased Expression of Adhesion Molecules in Uremic Atherosclerosis in Apolipoprotein-E-Deficient Mice J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1495 - 1503. [Abstract] [Full Text] [PDF]

				G. Gabbiani Control of Smooth Muscle Cell Activation Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 804 - 805. [Full Text]

				R. C. Braun-Dullaeus, M. J. Mann, D. G. Sedding, S. W. Sherwood, H. E. von der Leyen, and V. J. Dzau Cell Cycle-Dependent Regulation of Smooth Muscle Cell Activation Arterioscler Thromb Vasc Biol, May 1, 2004; 24(5): 845 - 850. [Abstract] [Full Text]

				P. A. Henriksen, M. Hitt, Z. Xing, J. Wang, C. Haslett, R. A. Riemersma, D. J. Webb, Y. V. Kotelevtsev, and J.-M. Sallenave Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-{kappa}B-Dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli J. Immunol., April 1, 2004; 172(7): 4535 - 4544. [Abstract] [Full Text] [PDF]

				J.-W. Chen, Y.-H. Chen, F.-Y. Lin, Y.-L. Chen, and S.-J. Lin Ginkgo biloba Extract Inhibits Tumor Necrosis Factor-{alpha}-Induced Reactive Oxygen Species Generation, Transcription Factor Activation, and Cell Adhesion Molecule Expression in Human Aortic Endothelial Cells Arterioscler Thromb Vasc Biol, September 1, 2003; 23(9): 1559 - 1566. [Abstract] [Full Text] [PDF]

				H. Yoneda, K. Miura, H. Matsushima, K. Sugi, T. Murakami, K. Ouchi, K. Yamashita, H. Itoh, T. Nakazawa, M. Suzuki, et al. Aspirin inhibits Chlamydia pneumoniae-induced NF-{kappa}B activation, cyclo-oxygenase-2 expression and prostaglandin E2 synthesis and attenuates chlamydial growth J. Med. Microbiol., May 1, 2003; 52(5): 409 - 415. [Abstract] [Full Text] [PDF]

				R. Carlisle, C. A. Rhoads, T. Y. Aw, and L. Harrison Endothelial cells maintain a reduced redox environment even as mitochondrial function declines Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1675 - C1686. [Abstract] [Full Text] [PDF]

				P J Sheridan and D C Crossman Critical review of unstable angina and non-ST elevation myocardial infarction Postgrad. Med. J., December 1, 2002; 78(926): 717 - 726. [Abstract] [Full Text] [PDF]

				N.T. Mulvihill, B. Foley, P. Crean, and M. Walsh Prediction of cardiovascular risk using soluble cell adhesion molecules Eur. Heart J., October 2, 2002; 23(20): 1569 - 1574. [Full Text] [PDF]

				A. A. El-Solh, M. J. Mador, P. Sikka, R. S. Dhillon, D. Amsterdam, and B. J. B. Grant Adhesion Molecules in Patients With Coronary Artery Disease and Moderate-to-Severe Obstructive Sleep Apnea* Chest, May 1, 2002; 121(5): 1541 - 1547. [Abstract] [Full Text] [PDF]

				T. Skoog, W. Dichtl, S. Boquist, C. Skoglund-Andersson, F. Karpe, R. Tang, M.G. Bond, U. de Faire, J. Nilsson, P. Eriksson, et al. Plasma tumour necrosis factor-{alpha} and early carotid atherosclerosis in healthy middle-aged men Eur. Heart J., March 1, 2002; 23(5): 376 - 383. [Abstract] [Full Text] [PDF]

				S. Abou-Raya, A. Naeem, H. A.-E. Kheir, and S. El Beltagy Coronary Artery Disease and Periodontal Disease: Is There a Link? Angiology, March 1, 2002; 53(2): 141 - 148. [Abstract] [PDF]

				M. E. Rosenfeld Leukocyte Recruitment Into Developing Atherosclerotic Lesions: The Complex Interaction Between Multiple Molecules Keeps Getting More Complex Arterioscler Thromb Vasc Biol, March 1, 2002; 22(3): 361 - 363. [Full Text] [PDF]

				N T Mulvihill and J B Foley Inflammation in acute coronary syndromes Heart, March 1, 2002; 87(3): 201 - 204. [Abstract] [Full Text] [PDF]

				G.F. Gensini and B. Dilaghi The unstable plaque Eur. Heart J. Suppl., March 1, 2002; 4(suppl_B): B22 - B27. [Abstract] [PDF]

				W.-J. ZHANG and B. FREI {alpha}-Lipoic acid inhibits TNF-{alpha}-induced NF-{kappa}B activation and adhesion molecule expression in human aortic endothelial cells FASEB J, November 1, 2001; 15(13): 2423 - 2432. [Abstract] [Full Text] [PDF]

				C. G. Kevil, R. P. Patel, and D. C. Bullard Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1442 - C1447. [Abstract] [Full Text] [PDF]

				M. Katoh, Y. Kurosawa, K. Tanaka, A. Watanabe, H. Doi, and H. Narita Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H655 - H660. [Abstract] [Full Text] [PDF]

				A.P. Simopoulos Evolutionary aspects of diet, essential fatty acids and cardiovascular disease Eur. Heart J. Suppl., June 1, 2001; 3(suppl_D): D8 - D21. [Abstract] [PDF]

				B. J. Van Lenten, A. C. Wagner, D. P. Nayak, S. Hama, M. Navab, and A. M. Fogelman High-Density Lipoprotein Loses Its Anti-Inflammatory Properties During Acute Influenza A Infection Circulation, May 8, 2001; 103(18): 2283 - 2288. [Abstract] [Full Text] [PDF]

				G. E. Rainger and G. B. Nash Cellular Pathology of Atherosclerosis : Smooth Muscle Cells Prime Cocultured Endothelial Cells for Enhanced Leukocyte Adhesion Circ. Res., March 30, 2001; 88(6): 615 - 622. [Abstract] [Full Text] [PDF]

				R. Voisard, R. Fischer, M. O{beta}wald, S. Voglic, R. Baur, M. Susa, W. Koenig, and V. Hombach Aspirin (5 mmol/L) Inhibits Leukocyte Attack and Triggered Reactive Cell Proliferation in a 3D Human Coronary In Vitro Model Circulation, March 27, 2001; 103(12): 1688 - 1694. [Abstract] [Full Text] [PDF]

				M. Otsuki, H. Saito, X. Xu, S. Sumitani, H. Kouhara, T. Kishimoto, and S. Kasayama Progesterone, but Not Medroxyprogesterone, Inhibits Vascular Cell Adhesion Molecule-1 Expression in Human Vascular Endothelial Cells Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 243 - 248. [Abstract] [Full Text] [PDF]

				J. Hulthe, O. Wiklund, E. Hurt-Camejo, and G. Bondjers Antibodies to Oxidized LDL in Relation to Carotid Atherosclerosis, Cell Adhesion Molecules, and Phospholipase A2 Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 269 - 274. [Abstract] [Full Text] [PDF]

				G. W. Cockerill, T. Y. Huehns, A. Weerasinghe, C. Stocker, P. G. Lerch, N. E. Miller, and D. O. Haskard Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1-Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation Circulation, January 2, 2001; 103(1): 108 - 112. [Abstract] [Full Text] [PDF]

				M.-C. Bourdillon, R. N. Poston, C. Covacho, E. Chignier, G. Bricca, and J. L. McGregor ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE-/-/ICAM-1-/-) Fed a Fat or a Chow Diet Arterioscler Thromb Vasc Biol, December 1, 2000; 20(12): 2630 - 2635. [Abstract] [Full Text] [PDF]

				N. T. Mulvihill, J. B. Foley, R. Murphy, P. Crean, and M. Walsh Evidence of prolonged inflammation in unstable angina and non-Q wave myocardial infarction J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1210 - 1216. [Abstract] [Full Text] [PDF]

				K. Zibara, E. Chignier, C. Covacho, R. Poston, G. Canard, P. Hardy, and J. McGregor Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet-Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E-Deficient Compared With Wild-Type Mice Arterioscler Thromb Vasc Biol, October 1, 2000; 20(10): 2288 - 2296. [Abstract] [Full Text] [PDF]

				T. M. Calderon, S. D. Gertz, I. J. Sarembock, J. A. Berliner, J. T. Fallon, M. B. Taubman, and J. W. Berman Induction of IG9 Monocyte Adhesion Molecule Expression in Smooth Muscle and Endothelial Cells After Balloon Arterial Injury in Cholesterol-Fed Rabbits Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1293 - 1300. [Abstract] [Full Text] [PDF]

				Y. Zou, Y. Hu, M. Mayr, H. Dietrich, G. Wick, and Q. Xu Reduced Neointima Hyperplasia of Vein Bypass Grafts in Intercellular Adhesion Molecule-1-Deficient Mice Circ. Res., March 3, 2000; 86(4): 434 - 440. [Abstract] [Full Text] [PDF]

				H. Dietrich, Y. Hu, Y. Zou, S. Dirnhofer, R. Kleindienst, G. Wick, and Q. Xu Mouse Model of Transplant Arteriosclerosis : Role of Intercellular Adhesion Molecule-1 Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 343 - 352. [Abstract] [Full Text] [PDF]

				R. G. Collins, R. Velji, N. V. Guevara, M. J. Hicks, L. Chan, and A. L. Beaudet P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice J. Exp. Med., January 3, 2000; 191(1): 189 - 194. [Abstract] [Full Text] [PDF]

				R. De Caterina, J. K Liao, and P. Libby Fatty acid modulation of endothelial activation Am. J. Clinical Nutrition, January 1, 2000; 71(1): 213S - 223S. [Abstract] [Full Text] [PDF]

				Y. Hu, H. Dietrich, B. Metzler, G. Wick, and Q. Xu Hyperexpression and Activation of Extracellular Signal-Regulated Kinases (ERK1/2) in Atherosclerotic Lesions of Cholesterol-Fed Rabbits Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 18 - 26. [Abstract] [Full Text] [PDF]

				S. Hoshida, N. Yamashita, K. Otsu, T. Kuzuya, and M. Hori Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H256 - H262. [Abstract] [Full Text] [PDF]

				K. Jaakkola, K. Kaunismaki, S. Tohka, G. Yegutkin, E. Vanttinen, T. Havia, L. J. Pelliniemi, M. Virolainen, S. Jalkanen, and M. Salmi Human Vascular Adhesion Protein-1 in Smooth Muscle Cells Am. J. Pathol., December 1, 1999; 155(6): 1953 - 1965. [Abstract] [Full Text] [PDF]

				S. Massberg, G. Enders, F. C. d. M. Matos, L. I. D. Tomic, R. Leiderer, S. Eisenmenger, K. Messmer, and F. Krombach Fibrinogen Deposition at the Postischemic Vessel Wall Promotes Platelet Adhesion During Ischemia-Reperfusion In Vivo Blood, December 1, 1999; 94(11): 3829 - 3838. [Abstract] [Full Text] [PDF]

				P. Xia, M. A. Vadas, K.-A. Rye, P. J. Barter, and J. R. Gamble High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway. A POSSIBLE MECHANISM FOR PROTECTION AGAINST ATHEROSCLEROSIS BY HDL J. Biol. Chem., November 12, 1999; 274(46): 33143 - 33147. [Abstract] [Full Text] [PDF]

				G. Walker, A. C. Langheinrich, E. Dennhauser, R. M. Bohle, T. Dreyer, J. Kreuzer, H. Tillmanns, R. C. Braun-Dullaeus, and W. Haberbosch 3-Deazaadenosine Prevents Adhesion Molecule Expression and Atherosclerotic Lesion Formation in the Aortas of C57BL/6J Mice Arterioscler Thromb Vasc Biol, November 1, 1999; 19(11): 2673 - 2679. [Abstract] [Full Text] [PDF]

				L. Pastore, A. Tessitore, S. Martinotti, E. Toniato, E. Alesse, M. C. Bravi, C. Ferri, G. Desideri, A. Gulino, and A. Santucci Angiotensin II Stimulates Intercellular Adhesion Molecule-1 (ICAM-1) Expression by Human Vascular Endothelial Cells and Increases Soluble ICAM-1 Release In Vivo Circulation, October 12, 1999; 100(15): 1646 - 1652. [Abstract] [Full Text] [PDF]

				Y. V Bobryshev, S. M Cherian, S. J Inder, and R. S.A Lord Neovascular expression of VE-cadherin in human atherosclerotic arteries and its relation to intimal inflammation Cardiovasc Res, September 1, 1999; 43(4): 1003 - 1017. [Abstract] [Full Text] [PDF]

				H. Kataoka, N. Kume, S. Miyamoto, M. Minami, H. Moriwaki, T. Murase, T. Sawamura, T. Masaki, N. Hashimoto, and T. Kita Expression of Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 in Human Atherosclerotic Lesions Circulation, June 22, 1999; 99(24): 3110 - 3117. [Abstract] [Full Text] [PDF]

				C. L. Ramos, Y. Huo, U. Jung, S. Ghosh, D. R. Manka, I. J. Sarembock, and K. Ley Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice Circ. Res., June 11, 1999; 84(11): 1237 - 1244. [Abstract] [Full Text] [PDF]

				D. J. Lefer and D. N. Granger Monocyte Rolling in Early Atherogenesis : Vital Role in Lesion Development Circ. Res., June 11, 1999; 84(11): 1353 - 1355. [Full Text] [PDF]

				T. Murase, N. Kume, T. Hase, Y. Shibuya, Y. Nishizawa, I. Tokimitsu, and T. Kita Gallates Inhibit Cytokine-Induced Nuclear Translocation of NF-{kappa}B and Expression of Leukocyte Adhesion Molecules in Vascular Endothelial Cells Arterioscler Thromb Vasc Biol, June 1, 1999; 19(6): 1412 - 1420. [Abstract] [Full Text] [PDF]

				K. S.C. Weber, G. Draude, W. Erl, R. de Martin, and C. Weber Monocyte Arrest and Transmigration on Inflamed Endothelium in Shear Flow Is Inhibited by Adenovirus-Mediated Gene Transfer of Ikappa B-alpha Blood, June 1, 1999; 93(11): 3685 - 3693. [Abstract] [Full Text] [PDF]

				G. W. Cockerill, J. Saklatvala, S. H. Ridley, H. Yarwood, N. E. Miller, B. Oral, S. Nithyanathan, G. Taylor, and D. O. Haskard High-Density Lipoproteins Differentially Modulate Cytokine-Induced Expression of E-Selectin and Cyclooxygenase-2 Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 910 - 917. [Abstract] [Full Text] [PDF]

				M. Klouche, A. E. May, M. Hemmes, M. Meßner, S. M. Kanse, K. T. Preissner, and S. Bhakdi Enzymatically Modified, Nonoxidized LDL Induces Selective Adhesion and Transmigration of Monocytes and T-Lymphocytes Through Human Endothelial Cell Monolayers Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 784 - 793. [Abstract] [Full Text] [PDF]

				M. Braun, P. Pietsch, K. Schror, G. Baumann, and S. B. Felix Cellular adhesion molecules on vascular smooth muscle cells Cardiovasc Res, February 1, 1999; 41(2): 395 - 401. [Abstract] [Full Text] [PDF]

				O. J. de Boer, A. C. van der Wal, P. Teeling, and A. E. Becker Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization? Cardiovasc Res, February 1, 1999; 41(2): 443 - 449. [Abstract] [Full Text] [PDF]

				L. Totani, A. Cumashi, A. Piccoli, and R. Lorenzet Polymorphonuclear Leukocytes Induce PDGF Release From IL-1ß–Treated Endothelial Cells : Role of Adhesion Molecules and Serine Proteases Arterioscler Thromb Vasc Biol, October 1, 1998; 18(10): 1534 - 1540. [Abstract] [Full Text] [PDF]

				A. E. May, S. M. Kanse, L. R. Lund, R. H. Gisler, B. A. Imhof, and K. T. Preissner Urokinase Receptor (CD87) Regulates Leukocyte Recruitment via {beta}2 Integrins In Vivo J. Exp. Med., September 21, 1998; 188(6): 1029 - 1037. [Abstract] [Full Text] [PDF]

				N. Marx, F.-J. Neumann, D. Zohlnhofer, T. Dickfeld, A. Fischer, S. Heimerl, and A. Schomig Enhancement of Monocyte Procoagulant Activity by Adhesion on Vascular Smooth Muscle Cells and Intercellular Adhesion Molecule-1–Transfected Chinese Hamster Ovary Cells Circulation, September 1, 1998; 98(9): 906 - 911. [Abstract] [Full Text] [PDF]

				P. Libby The interface of atherosclerosis and thrombosis: basic mechanisms Vascular Medicine, August 1, 1998; 3(3): 225 - 229. [Abstract] [PDF]

				M. Tamaru, K. Tomura, S. Sakamoto, K. Tezuka, T. Tamatani, and S. Narumi Interleukin-1ß Induces Tissue- and Cell Type–Specific Expression of Adhesion Molecules In Vivo Arterioscler Thromb Vasc Biol, August 1, 1998; 18(8): 1292 - 1303. [Abstract] [Full Text] [PDF]

				T. J. DeGraba, A.-L. Siren, L. Penix, R. M. McCarron, R. Hargraves, S. Sood, K. D. Pettigrew, and J. M. Hallenbeck Increased Endothelial Expression of Intercellular Adhesion Molecule-1 in Symptomatic Versus Asymptomatic Human Carotid Atherosclerotic Plaque Stroke, July 1, 1998; 29(7): 1405 - 1410. [Abstract] [Full Text] [PDF]

				A. H. Chester, K. J.M. Morrison, and M. H. Yacoub Expression of Vascular Adhesion Molecules in Saphenous Vein Coronary Bypass Grafts Ann. Thorac. Surg., June 1, 1998; 65(6): 1685 - 1689. [Abstract] [Full Text] [PDF]

				F. Calara, P. Dimayuga, A. Niemann, J. Thyberg, U. Diczfalusy, J. L. Witztum, W. Palinski, P. K. Shah, B. Cercek, J. Nilsson, et al. An Animal Model to Study Local Oxidation of LDL and Its Biological Effects in the Arterial Wall Arterioscler Thromb Vasc Biol, June 1, 1998; 18(6): 884 - 893. [Abstract] [Full Text] [PDF]

				P. M. Ridker Inflammation, Infection, and Cardiovascular Risk : How Good Is the Clinical Evidence? Circulation, May 5, 1998; 97(17): 1671 - 1674. [Full Text] [PDF]

				Y. Abe, B. El-Masri, K. T. Kimball, H. Pownall, C. F. Reilly, K. Osmundsen, C. W. Smith, and C. M. Ballantyne Soluble Cell Adhesion Molecules in Hypertriglyceridemia and Potential Significance on Monocyte Adhesion Arterioscler Thromb Vasc Biol, May 1, 1998; 18(5): 723 - 731. [Abstract] [Full Text] [PDF]

				S. Sugiyama, K. Kugiyama, N. Ogata, H. Doi, Y. Ota, M. Ohgushi, T. Matsumura, H. Oka, and H. Yasue Biphasic Regulation of Transcription Factor Nuclear Factor-{kappa}B Activity in Human Endothelial Cells by Lysophosphatidylcholine Through Protein Kinase C–Mediated Pathway Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 568 - 576. [Abstract] [Full Text] [PDF]

				S. Takami, S. Yamashita, S. Kihara, M. Ishigami, K. Takemura, N. Kume, T. Kita, and Y. Matsuzawa Lipoprotein(a) Enhances the Expression of Intercellular Adhesion Molecule-1 in Cultured Human Umbilical Vein Endothelial Cells Circulation, March 3, 1998; 97(8): 721 - 728. [Abstract] [Full Text] [PDF]

				S. S. Patel, R. Thiagarajan, J. T. Willerson, and E. T. H. Yeh Inhibition of {alpha}4 Integrin and ICAM-1 Markedly Attenuate Macrophage Homing to Atherosclerotic Plaques in ApoE-Deficient Mice Circulation, January 13, 1998; 97(1): 75 - 81. [Abstract] [Full Text] [PDF]

				S.-J. Hwang, C. M. Ballantyne, A. R. Sharrett, L. C. Smith, C. E. Davis, A. M. Gotto Jr, and E. Boerwinkle Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases : The Atherosclerosis Risk In Communities (ARIC) Study Circulation, December 16, 1997; 96(12): 4219 - 4225. [Abstract] [Full Text]

				M. Braun, P. Pietsch, A. Zepp, K. Schror, G. Baumann, and S. B. Felix Regulation of Tumor Necrosis Factor-{alpha} and Interleukin-1ß Induced Adhesion Molecule Expression in Human Vascular Smooth Muscle Cells by cAMP Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2568 - 2575. [Abstract] [Full Text]

				S. Hoshida, N. Yamashita, J. Igarashi, K. Aoki, T. Kuzuya, and M. Hori Long-term Probucol Treatment Reverses the Severity of Myocardial Injury in Watanabe Heritable Hyperlipidemic Rabbits Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2801 - 2807. [Abstract] [Full Text]

				C. A. Labarrere, D. R. Nelson, and W. P. Faulk Endothelial Activation and Development of Coronary Artery Disease in Transplanted Human Hearts JAMA, October 8, 1997; 278(14): 1169 - 1175. [Abstract] [PDF]

				K. Brand, T. Eisele, U. Kreusel, M. Page, S. Page, M. Haas, A. Gerling, C. Kaltschmidt, F.-J. Neumann, N. Mackman, et al. Dysregulation of Monocytic Nuclear Factor-{kappa}B by Oxidized Low-Density Lipoprotein Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 1901 - 1909. [Abstract] [Full Text]

				M. F. Nageh, E. T. Sandberg, K. R. Marotti, A. H. Lin, E. P. Melchior, D. C. Bullard, and A. L. Beaudet Deficiency of Inflammatory Cell Adhesion Molecules Protects Against Atherosclerosis in Mice Arterioscler Thromb Vasc Biol, August 1, 1997; 17(8): 1517 - 1520. [Abstract] [Full Text]

				L. M. McEvoy, H. Sun, P. S. Tsao, J. P. Cooke, J. A. Berliner, and E. C. Butcher Novel Vascular Molecule Involved in Monocyte Adhesion to Aortic Endothelium in Models of Atherogenesis J. Exp. Med., June 16, 1997; 185(12): 2069 - 2077. [Abstract] [Full Text] [PDF]

				H. Yasukawa, T. Imaizumi, H. Matsuoka, A. Nakashima, and M. Morimatsu Inhibition of Intimal Hyperplasia After Balloon Injury by Antibodies to Intercellular Adhesion Molecule-1 and Lymphocyte Function–Associated Antigen-1 Circulation, March 18, 1997; 95(6): 1515 - 1522. [Abstract] [Full Text]

				C. F. Bennett, D. Kornbrust, S. Henry, K. Stecker, R. Howard, S. Cooper, S. Dutson, W. Hall, and H. I. Jacoby An ICAM-1 Antisense Oligonucleotide Prevents and Reverses Dextran Sulfate Sodium-Induced Colitis in Mice J. Pharmacol. Exp. Ther., February 1, 1997; 280(2): 988 - 1000. [Abstract] [Full Text]

				A. Sakai, N. Kume, E. Nishi, K. Tanoue, M. Miyasaka, and T. Kita P-Selectin and Vascular Cell Adhesion Molecule-1 Are Focally Expressed in Aortas of Hypercholesterolemic Rabbits Before Intimal Accumulation of Macrophages and T Lymphocytes Arterioscler Thromb Vasc Biol, February 1, 1997; 17(2): 310 - 316. [Abstract] [Full Text]

				C. Duplaa, T. Couffinhal, P. Dufourcq, B. Llanas, C. Moreau, and J. Bonnet The Integrin Very Late Antigen-4 Is Expressed in Human Smooth Muscle Cell: Involvement of {alpha}4 and Vascular Cell Adhesion Molecule-1 During Smooth Muscle Cell Differentiation Circ. Res., February 1, 1997; 80(2): 159 - 169. [Abstract] [Full Text]

				A. Duperray, L. R. Languino, J. Plescia, A. McDowall, N. Hogg, A. G. Craig, A. R. Berendt, and D. C. Altieri Molecular Identification of a Novel Fibrinogen Binding Site on the First Domain of ICAM-1 Regulating Leukocyte-Endothelium Bridging J. Biol. Chem., January 3, 1997; 272(1): 435 - 441. [Abstract] [Full Text] [PDF]

				M. Endres, U. Laufs, H. Merz, and M. Kaps Focal Expression of Intercellular Adhesion Molecule-1 in the Human Carotid Bifurcation Stroke, January 1, 1997; 28(1): 77 - 82. [Abstract] [Full Text]

				M. Mai, K. F. Hilgers, and H. Geiger Experimental Studies on the Role of Intercellular Adhesion Molecule-1 and Lymphocyte Function–Associated Antigen-1 in Hypertensive Nephrosclerosis Hypertension, December 1, 1996; 28(6): 973 - 979. [Abstract] [Full Text]

				X. Wang, T.-L. Yue, E. H. Ohlstein, C.-P. Sung, and G. Z. Feuerstein Interferon-inducible Protein-10 Involves Vascular Smooth Muscle Cell Migration, Proliferation, and Inflammatory Response J. Biol. Chem., September 27, 1996; 271(39): 24286 - 24293. [Abstract] [Full Text] [PDF]

				M. Kaneko, J. Hayashi, I. Saito, and N. Miyasaka Probucol Downregulates E-Selectin Expression on Cultured Human Vascular Endothelial Cells Arterioscler Thromb Vasc Biol, August 1, 1996; 16(8): 1047 - 1051. [Abstract] [Full Text]

				W. S. Shin, Y.-H. Hong, H.-B. Peng, R. De Caterina, P. Libby, and J. K. Liao Nitric Oxide Attenuates Vascular Smooth Muscle Cell Activation by Interferon-[IMAGE] J. Biol. Chem., May 10, 1996; 271(19): 11317 - 11324. [Abstract] [Full Text] [PDF]

				A. Hackman, Y. Abe, W. Insull Jr, H. Pownall, L. Smith, K. Dunn, A. M. Gotto Jr, and C. M. Ballantyne Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia Circulation, April 1, 1996; 93(7): 1334 - 1338. [Abstract] [Full Text]

				K. D. O'Brien, T. O. McDonald, A. Chait, M. D. Allen, and C. E. Alpers Neovascular Expression of E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Human Atherosclerosis and Their Relation to Intimal Leukocyte Content Circulation, February 15, 1996; 93(4): 672 - 682. [Abstract] [Full Text]

				H. Tanaka, G. Sukhova, D. Schwartz, and P. Libby Proliferating Arterial Smooth Muscle Cells After Balloon Injury Express TNF-{alpha} but Not Interleukin-1 or Basic Fibroblast Growth Factor Arterioscler Thromb Vasc Biol, January 1, 1996; 16(1): 12 - 18. [Abstract] [Full Text]