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American Journal of Pathology, Vol 140, 981-989, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Clonal Epstein-Barr virus genome in T-cell-rich lymphomas of B or probable B lineage

SL Loke, F Ho, G Srivastava, KH Fu, B Leung and R Liang
Department of Pathology, University of Hong Kong, Queen Mary Hospital.

Seventeen nodal lymphomas (originally diagnosed as T-cell lymphomas based on histological features and immunohistochemical staining results) were studied for the presence of Epstein-Barr virus (EBV) genome, and the results correlated with immunoglobulin and T-cell receptor gene rearrangement analyses performed on the same tissue samples. All four EBV positive cases had clonal rearrangement of the joining region of the immunoglobulin heavy chain (IgJH) gene without clonal T-cell receptor beta-chain (TCR beta) gene rearrangement. Of these, two cases also showed clonally rearranged light chain gene, and they were reclassified as T-cell rich B-cell lymphomas (TRBL). The other two cases lacked clonal kappa or lambda light chain rearrangement and they were reclassified as T-cell rich lymphomas of probable B lineage, based on their isolated IgJH clonal rearrangement. These B- cell lymphomas may be easily misdiagnosed as T-cell lymphomas owing to the presence of an abundant reactive T-cell infiltrate masking the tumor population. The florid T-cell reaction may represent an unusual host response towards a clonal proliferation of EBV bearing B cells.


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Copyright © 1992 by the American Society for Investigative Pathology.