This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Muramoto, T. Articles by Goto, I. Search for Related Content PubMed PubMed Citation Articles by Muramoto, T. Articles by Goto, I.

American Journal of Pathology, Vol 140, 1411-1420, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease

T Muramoto, T Kitamoto, J Tateishi and I Goto
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

The distribution and sequential development of prion protein (PrP) accumulation in the central nervous system (CNS) and non-neuronal organs of mice infected with Creutzfeldt-Jakob disease (CJD) were investigated immunohistochemically using a new pretreatment method that greatly enhanced the immunoreactivity of PrP. Prion protein accumulation in the CNS was first detected at 30 days after inoculation and then developed near the inoculation site or periventricular area, and later spread to the whole cerebrum and then to the pons. Its staining took some characteristic forms. Among non-neuronal organs, PrP accumulated in the follicular dendritic cells (FDCs) in spleen, lymph node, Peyer's patch, and thymus. FDCs staining appeared in spleen, lymph node, and Peyer's patch at 21 or 30 days after inoculation, and in thymus at 90 days. Germinal centers developed in the thymus of some CJD-infected mice. No PrP staining was detected in any examined organs of age-matched control mice.

This article has been cited by other articles:

				G. Legname, H.-O. B. Nguyen, D. Peretz, F. E. Cohen, S. J. DeArmond, and S. B. Prusiner Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes PNAS, December 12, 2006; 103(50): 19105 - 19110. [Abstract] [Full Text] [PDF]

				G. Tamguney, K. Giles, E. Bouzamondo-Bernstein, P. J. Bosque, M. W. Miller, J. Safar, S. J. DeArmond, and S. B. Prusiner Transmission of elk and deer prions to transgenic mice. J. Virol., September 1, 2006; 80(18): 9104 - 9114. [Abstract] [Full Text] [PDF]

				M. R. Scott, D. Peretz, H.-O. B. Nguyen, S. J. DeArmond, and S. B. Prusiner Transmission Barriers for Bovine, Ovine, and Human Prions in Transgenic Mice J. Virol., May 1, 2005; 79(9): 5259 - 5271. [Abstract] [Full Text] [PDF]

				G. Legname, H.-O. B. Nguyen, I. V. Baskakov, F. E. Cohen, S. J. DeArmond, and S. B. Prusiner Strain-specified characteristics of mouse synthetic prions PNAS, February 8, 2005; 102(6): 2168 - 2173. [Abstract] [Full Text] [PDF]

				M. D. Geschwind, J. Martindale, D. Miller, S. J. DeArmond, J. Uyehara-Lock, D. Gaskin, J. H. Kramer, N. M. Barbaro, and B. L. Miller Challenging the Clinical Utility of the 14-3-3 Protein for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease Arch Neurol, June 1, 2003; 60(6): 813 - 816. [Abstract] [Full Text] [PDF]

				J. Martindale, M. D. Geschwind, S. De Armond, G. Young, W. P. Dillon, R. Henry, J. H. Uyehara-Lock, D. A. Gaskin, and B. L. Miller Sporadic Creutzfeldt-Jakob Disease Mimicking Variant Creutzfeldt-Jakob Disease Arch Neurol, May 1, 2003; 60(5): 767 - 770. [Abstract] [Full Text] [PDF]

				H. Lewicki, A. Tishon, D. Homann, H. Mazarguil, F. Laval, V. C. Asensio, I. L. Campbell, S. DeArmond, B. Coon, C. Teng, et al. T Cells Infiltrate the Brain in Murine and Human Transmissible Spongiform Encephalopathies J. Virol., March 15, 2003; 77(6): 3799 - 3808. [Abstract] [Full Text] [PDF]

				V. Perrier, K. Kaneko, J. Safar, J. Vergara, P. Tremblay, S. J. DeArmond, F. E. Cohen, S. B. Prusiner, and A. C. Wallace Dominant-negative inhibition of prion replication in transgenic mice PNAS, October 1, 2002; 99(20): 13079 - 13084. [Abstract] [Full Text] [PDF]

				J. A. Mastrianni, S. Capellari, G. C. Telling, D. Han, P. Bosque, S. B. Prusiner, and S. J. DeArmond Inherited prion disease caused by the V210I mutation: Transmission to transgenic mice Neurology, December 26, 2001; 57(12): 2198 - 2205. [Abstract] [Full Text] [PDF]

				S. Supattapone, T. Muramoto, G. Legname, I. Mehlhorn, F. E. Cohen, S. J. DeArmond, S. B. Prusiner, and M. R. Scott Identification of Two Prion Protein Regions That Modify Scrapie Incubation Time J. Virol., February 1, 2001; 75(3): 1408 - 1413. [Abstract] [Full Text]

				F. Montrasio, R. Frigg, M. Glatzel, M. A. Klein, F. Mackay, A. Aguzzi, and C. Weissmann Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic Cells Science, May 19, 2000; 288(5469): 1257 - 1259. [Abstract] [Full Text]

				M. R. Scott, R. Will, J. Ironside, H.-O. B. Nguyen, P. Tremblay, S. J. DeArmond, and S. B. Prusiner From the Cover: Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans PNAS, December 21, 1999; 96(26): 15137 - 15142. [Abstract] [Full Text] [PDF]

				A. J. Raeber, A. Sailer, I. Hegyi, M. A. Klein, T. Rulicke, M. Fischer, S. Brandner, A. Aguzzi, and C. Weissmann Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication PNAS, March 30, 1999; 96(7): 3987 - 3992. [Abstract] [Full Text] [PDF]

				M. R. Scott, J. Safar, G. Telling, O. Nguyen, D. Groth, M. Torchia, R. Koehler, P. Tremblay, D. Walther, F. E. Cohen, et al. Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice PNAS, December 23, 1997; 94(26): 14279 - 14284. [Abstract] [Full Text] [PDF]

				G C Telling, T Haga, M Torchia, P Tremblay, S J DeArmond, and S B Prusiner Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes & Dev., July 15, 1996; 10(14): 1736 - 1750. [Abstract] [PDF]

				H. E. M. McMahon, A. Mange, N. Nishida, C. Creminon, D. Casanova, and S. Lehmann Cleavage of the Amino Terminus of the Prion Protein by Reactive Oxygen Species J. Biol. Chem., January 12, 2001; 276(3): 2286 - 2291. [Abstract] [Full Text] [PDF]

				F. Montrasio, A. Cozzio, E. Flechsig, D. Rossi, M. A. Klein, T. Rulicke, A. J. Raeber, C. A. J. Vosshenrich, J. Proft, A. Aguzzi, et al. B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice PNAS, March 27, 2001; 98(7): 4034 - 4037. [Abstract] [Full Text] [PDF]

				C. Lemaire-Vieille, T. Schulze, V. Podevin-Dimster, J. Follet, Y. Bailly, F. Blanquet-Grossard, J.-P. Decavel, E. Heinen, and J.-Y. Cesbron Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice PNAS, May 9, 2000; 97(10): 5422 - 5427. [Abstract] [Full Text] [PDF]