help button home button Am J Pathol JNCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shea, C. R.
Right arrow Articles by Albino, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shea, C. R.
Right arrow Articles by Albino, A. P.

American Journal of Pathology, Vol 141, 25-29, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Overexpression of p53 protein in basal cell carcinomas of human skin

CR Shea, NS McNutt, M Volkenandt, J Lugo, PG Prioleau and AP Albino
Department of Pathology, New York Hospital-Cornell Medical Center, New York 10021.

Basal cell carcinoma (BCC) of the skin is the most common human cancer, but its molecular-genetic pathogenesis is unclear. In many other types of cancer, mutations of the tumor-suppressor gene p53 occur frequently and may lead to overexpression of a long-lived mutant form of p53 protein. In this study, overexpression of p53 protein was detected immunohistochemically in 30 (83%) of 36 specimens of BCC of the head and neck. The same regions of tumor typically were reactive both with a monoclonal antibody (PAb240) specific for the mutant protein and with one (PAb1801) directed against an epitope common to both wild-type and mutant p53 protein. Keratinocytes of chronically sun-exposed epidermis adjacent to BCCs also focally overexpressed p53 protein in the majority of cases, whereas those of sun-protected buttock skin did not. Mutation of p53 may form an important part of the pathogenetic sequence in a majority of cases of BCC.


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. G. Einspahr, M.-J. Xu, J. Warneke, K. Saboda, J. Ranger-Moore, P. Bozzo, L. Duckett, R. Goldman, P. Lin, J. Buckmeier, et al.
Reproducibility and Expression of Skin Biomarkers in Sun-Damaged Skin and Actinic Keratoses
Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1841 - 1848.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
M. Heckmann, F. Zogelmeier, and B. Konz
Frequency of Facial Basal Cell Carcinoma Does Not Correlate With Site-Specific UV Exposure
Arch Dermatol, November 1, 2002; 138(11): 1494 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
H. Tsao
Genetics of Nonmelanoma Skin Cancer
Arch Dermatol, November 1, 2001; 137(11): 1486 - 1492.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the American Society for Investigative Pathology.