| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 141, 881-886, Copyright © 1992 by American Society for Investigative Pathology
REGULAR ARTICLES |
J Dalmau, HM Furneaux, C Cordon-Cardo and JB Posner
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Using immunohistochemistry or Western blot analysis, the authors have studied the expression of the Hu antigen (a neuronal protein identified by the serum of patients with small cell lung cancer and paraneoplastic encephalomyelitis/sensory neuronopathy) in normal human tissues and 115 tumors of different histologic types. In normal tissue, the Hu antigen is highly restricted to the nervous system. In lung tumors, the Hu antigen is restricted in its expression to all small cell carcinomas. A few other neuroendocrine-related tumors, especially neuroblastomas (50%), also express the antigen.
This article has been cited by other articles:
 |
|
 |
|
  T. Fujiwara, Y. Mori, D. L. Chu, Y. Koyama, S. Miyata, H. Tanaka, K. Yachi, T. Kubo, H. Yoshikawa, and M. Tohyama CARM1 Regulates Proliferation of PC12 Cells by Methylating HuD. Mol. Cell. Biol., March 1, 2006; 26(6): 2273 - 2285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Swerts, B. De Moerloose, C. Dhooge, J. Vandesompele, C. Hoyoux, K. Beiske, Y. Benoit, G. Laureys, and J. Philippe Potential Application of ELAVL4 Real-Time Quantitative Reverse Transcription-PCR for Detection of Disseminated Neuroblastoma Cells Clin. Chem., March 1, 2006; 52(3): 438 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Tschernatsch, E Stolz, M Strittmatter, M Kaps, and F Blaes Antinuclear antibodies define a subgroup of paraneoplastic neuropathies: clinical and immunological data J. Neurol. Neurosurg. Psychiatry, December 1, 2005; 76(12): 1702 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Ances, R. Vitaliani, R. A. Taylor, D. S. Liebeskind, A. Voloschin, D. J. Houghton, S. L. Galetta, M. Dichter, A. Alavi, M. R. Rosenfeld, et al. Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates Brain, August 1, 2005; 128(8): 1764 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Darnell Tumor Immunity in Small-Cell Lung Cancer J. Clin. Oncol., March 1, 2004; 22(5): 762 - 764. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kasashima, E. Sakashita, K. Saito, and H. Sakamoto Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins Nucleic Acids Res., October 15, 2002; 30(20): 4519 - 4526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Amato and M. P. Anderson Case 38-2001- A 51-Year-Old Woman with Lung Cancer and Neuropsychiatric Abnormalities N. Engl. J. Med., December 13, 2001; 345(24): 1758 - 1765. [Full Text] [PDF]
|
|
|
|
|
|
F. Graus, F. Keime-Guibert, R. Rene, B. Benyahia, T. Ribalta, C. Ascaso, G. Escaramis, and J. Y. Delattre Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients Brain, June 1, 2001; 124(6): 1138 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Nabors, G. Y. Gillespie, L. Harkins, and P. H. King HuR, a RNA Stability Factor, Is Expressed in Malignant Brain Tumors and Binds to Adenine- and Uridine-rich Elements within the 3' Untranslated Regions of Cytokine and Angiogenic Factor mRNAs Cancer Res., March 1, 2001; 61(5): 2154 - 2161. [Abstract] [Full Text]
|
|
|
|
|
|
S. Park, D. G. Myszka, M. Yu, S. J. Littler, and I. A. Laird-Offringa HuD RNA Recognition Motifs Play Distinct Roles in the Formation of a Stable Complex with AU-Rich RNA Mol. Cell. Biol., July 1, 2000; 20(13): 4765 - 4772. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. H. Gultekin, J. Rosai, A. Demopoulos, Y. F. Graus, J. B. Posner, J. Dalmau, and M. K. Rosenblum Hu Immunolabeling as a Marker of Neural and Neuroendocrine Differentiation in Normal and Neoplastic Human Tissues: Assessment Using a Recombinant Anti-Hu Fab Fragment International Journal of Surgical Pathology, April 1, 2000; 8(2): 109 - 117. [Abstract] [PDF]
|
|
|
|
|
|
J. C. Darnell, M. L. Albert, and R. B. Darnell cdr2, a Target Antigen of Naturally Occurring Human Tumor Immunity, Is Widely Expressed in Gynecological Tumors Cancer Res., April 1, 2000; 60(8): 2136 - 2139. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Blaes, M. Klotz, H. Huwer, U. Straub, G. Kalweit, K. Schimrigk, and H.-J. Schafers Antineural and antinuclear autoantibodies are of prognostic relevance in non-small cell lung cancer Ann. Thorac. Surg., January 1, 2000; 69(1): 254 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Akamatsu, H. J. Okano, N. Osumi, T. Inoue, S. Nakamura, S.-I. Sakakibara, M. Miura, N. Matsuo, R. B. Darnell, and H. Okano Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems PNAS, August 17, 1999; 96(17): 9885 - 9890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Aranda-Abreu, L. Behar, S. Chung, H. Furneaux, and I. Ginzburg Embryonic Lethal Abnormal Vision-Like RNA-Binding Proteins Regulate Neurite Outgrowth and Tau Expression in PC12 Cells J. Neurosci., August 15, 1999; 19(16): 6907 - 6917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ohwada, I. Nagaoka, F. Takahashi, S. Tominaga, and Y. Fukuchi DNA Vaccination against HuD Antigen Elicits Antitumor Activity in a Small-Cell Lung Cancer Murine Model Am. J. Respir. Cell Mol. Biol., July 1, 1999; 21(1): 37 - 43. [Abstract] [Full Text]
|
|
|
|
|
|
R. Voltz, S. H. Gultekin, M. R. Rosenfeld, E. Gerstner, J. Eichen, J. B. Posner, and J. Dalmau A Serologic Marker of Paraneoplastic Limbic and Brain-Stem Encephalitis in Patients with Testicular Cancer N. Engl. J. Med., June 10, 1999; 340(23): 1788 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Darnell The Importance of Defining the Paraneoplastic Neurologic Disorders N. Engl. J. Med., June 10, 1999; 340(23): 1831 - 1833. [Full Text]
|
|
|
|
 |
|
 J. O. Dalmau and J. B. Posner Neurological Paraneoplastic Syndromes Neuroscientist, November 1, 1998; 4(6): 443 - 453. [PDF]
|
|
|
|
 |
|
 B. Joseph, M. Orlian, and H. Furneaux p21waf1 mRNA Contains a Conserved Element in Its 3'-Untranslated Region That Is Bound by the Elav-like mRNA-stabilizing Proteins J. Biol. Chem., August 7, 1998; 273(32): 20511 - 20516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Okano and R. B. Darnell A Hierarchy of Hu RNA Binding Proteins in Developing and Adult Neurons J. Neurosci., May 1, 1997; 17(9): 3024 - 3037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Corradi, C. Yang, J. C. Darnell, J. Dalmau, and R. B. Darnell A Post-Transcriptional Regulatory Mechanism Restricts Expression of the Paraneoplastic Cerebellar Degeneration Antigen cdr2 to Immune Privileged Tissues J. Neurosci., February 15, 1997; 17(4): 1406 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chagnovich, B. E. Fayos, and S. L. Cohn Differential Activity of ELAV-like RNA-binding Proteins in Human Neuroblastoma J. Biol. Chem., December 27, 1996; 271(52): 33587 - 33591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Caplan and D. N. Louis Case 30-1996- An 81-Year-Old Man with Progressive Disorientation, Repeated Falls, and a Fluctuating Mental State N. Engl. J. Med., September 26, 1996; 335(13): 952 - 959. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
