This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sasseville, V. G. Articles by Ringler, D. J. Search for Related Content PubMed PubMed Citation Articles by Sasseville, V. G. Articles by Ringler, D. J.

American Journal of Pathology, Vol 141, 1021-1030, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus

VG Sasseville, WA Newman, AA Lackner, MO Smith, NC Lausen, D Beall and DJ Ringler
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102.

AIDS encephalitis is a common sequela to HIV-1 infection in humans and simian immunodeficiency virus (SIVmac) infection in macaques. Although lentiviral-infected macrophages comprise parenchymal inflammatory infiltrates in affected brain tissue, the mechanisms responsible for leukocyte trafficking to the central nervous system in AIDS are unknown. In this study, we investigated the expression of various endothelial-derived leukocyte adhesion proteins in SIVmac-induced AIDS encephalitis. Encephalitic brains from SIVmac-infected macaques, but not uninflamed brains from other SIVmac-infected animals, were found to express abundant vascular cell adhesion molecule-1 (VCAM-1) protein on the majority of arteriolar, venular, and capillary endothelial cells. Soluble VCAM-1 concentrations in cerebrospinal fluid (CSF) from encephalitic animals were increased approximately 20-fold above those from animals without AIDS encephalitis. Expression of other endothelial- related adhesion molecules, including E-selectin, P-selectin, and intercellular adhesion molecule-1 (ICAM-1), was not uniformly associated with AIDS encephalitis. Thus, the presence of VCAM-1 in both brain and CSF was uniformly associated with SIVmac-induced disease of the central nervous system, and this expression may, at least in part, influence monocyte and lymphocyte recruitment to the central nervous system during the development of AIDS encephalitis. Moreover, measurement of soluble VCAM-1 in CSF may assist in the clinical assessment of animals or people with AIDS.

This article has been cited by other articles:

				E. A. Eugenin, R. Gamss, C. Buckner, D. Buono, R. S. Klein, E. E. Schoenbaum, T. M. Calderon, and J. W. Berman Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS. J. Leukoc. Biol., March 1, 2006; 79(3): 444 - 452. [Abstract] [Full Text] [PDF]

				N. V. Sipsas and P. P. Sfikakis Expanding Role of Circulating Adhesion Molecules in Assessing Prognosis and Treatment Response in Human Immunodeficiency Virus Infection Clin. Vaccine Immunol., November 1, 2004; 11(6): 996 - 1001. [Full Text] [PDF]

				X. Luo, K. A. Carlson, V. Wojna, R. Mayo, T. M. Biskup, J. Stoner, J. Anderson, H. E. Gendelman, and L. M. Melendez Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment Neurology, June 24, 2003; 60(12): 1931 - 1937. [Abstract] [Full Text] [PDF]

				Y. Miura, N. Misawa, Y. Kawano, H. Okada, Y. Inagaki, N. Yamamoto, M. Ito, H. Yagita, K. Okumura, H. Mizusawa, et al. Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection PNAS, March 4, 2003; 100(5): 2777 - 2782. [Abstract] [Full Text] [PDF]

				M. S. Orandle, A. G. MacLean, V. G. Sasseville, X. Alvarez, and A. A. Lackner Enhanced Expression of Proinflammatory Cytokines in the Central Nervous System Is Associated with Neuroinvasion by Simian Immunodeficiency Virus and the Development of Encephalitis J. Virol., May 3, 2002; 76(11): 5797 - 5802. [Abstract] [Full Text] [PDF]

				Y.-T. Shiu, M. M. Udden, and L. V. McIntire Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells Blood, May 15, 2000; 95(10): 3232 - 3241. [Abstract] [Full Text] [PDF]

				M. A. Simon, P. O. Ilyinskii, G. B. Baskin, H. Y. Knight, D. R. Pauley, and A. A. Lackner Association of Simian Virus 40 with a Central Nervous System Lesion Distinct from Progressive Multifocal Leukoencephalopathy in Macaques with AIDS Am. J. Pathol., February 1, 1999; 154(2): 437 - 446. [Abstract] [Full Text] [PDF]

				F. J. Novembre, J. De Rosayro, S. P. O'Neil, D. C. Anderson, S. A. Klumpp, and H. M. McClure Isolation and Characterization of a Neuropathogenic Simian Immunodeficiency Virus Derived from a Sooty Mangabey J. Virol., November 1, 1998; 72(11): 8841 - 8851. [Abstract] [Full Text] [PDF]

				H. E. d. Vries, J. Kuiper, A. G. d. Boer, T. J. C. V. Berkel, and D. D. Breimer The Blood-Brain Barrier in Neuroinflammatory Diseases Pharmacol. Rev., June 1, 1997; 49(2): 143 - 156. [Abstract] [Full Text] [PDF]