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American Journal of Pathology, Vol 141, 1037-1041, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Synaptophysin expression in "ependymal tumors" induced by ethyl- nitrosourea in rats

J Vaquero, S Coca, M Zurita, S Oya, A Arias, M Moreno and C Morales
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.

Synaptophysin expression was studied in seven "ependymomas" induced by transplacental administration of ethyl-nitrosourea in rats. In all the cases, strong positivity for synaptophysin was found on tumor cells. This finding supports previous studies suggesting that ENU-induced brain tumors considered to be ependymal neoplasms, are, in fact, primitive neuroectodermal tumors.


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B. C. Zook, S. J. Simmens, and R. V. Jones
Evaluation of ENU-Induced Gliomas in Rats: Nomenclature, Immunochemistry, and Malignancy
Toxicol Pathol, January 1, 2000; 28(1): 193 - 201.
[Abstract] [PDF]


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Copyright © 1992 by the American Society for Investigative Pathology.