This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Korhonen, M. Articles by Virtanen, I. Search for Related Content PubMed PubMed Citation Articles by Korhonen, M. Articles by Virtanen, I.

American Journal of Pathology, Vol 141, 1161-1171, Copyright © 1992 by American Society for Investigative Pathology

REGULAR ARTICLES

Integrin distributions in renal cell carcinomas of various grades of malignancy

M Korhonen, L Laitinen, J Ylanne, GK Koukoulis, V Quaranta, H Juusela, VE Gould and I Virtanen
Department of Anatomy, University of Helsinki, Finland.

We studied 41 renal cell carcinomas, classified according to histologic grades G1 through G3, by indirect immunofluorescence microscopy using a panel of monoclonal antibodies (MAb) against various integrin subunits, and the basement membrane (BM) components laminin and collagen type IV. Selected cases also were immunostained using the avidin-biotin-complex method. The alpha 3 and beta 1 integrin subunits were detected in tumor cells of all the carcinomas. All G1 carcinomas, like normal tubular epithelial cells, expressed the alpha 6 subunit, whereas it was lacking in 20% and 40% of G2 and G3 carcinomas, respectively. Furthermore, when alpha 6 was expressed, a lack of basally polarized organization of the subunit, coupled with disorganization of the BM components, correlated with histologic grade. Another feature that appeared to characterize the more anaplastic tumors was their high level (80%) of the alpha v subunit expression as compared with its absence in the G1 carcinomas. Stromal myofibroblasts, identified by double-labeling with anti-myosin, were often characterized by the expression of the alpha 1, alpha 3, alpha 5 and beta 1 subunits. These results indicate that changes in integrin expression in renal cell carcinomas may be correlated with their degree of histologic malignancy.

This article has been cited by other articles:

				N. Ahmed, C. Riley, G. E. Rice, M. A. Quinn, and M. S. Baker {alpha}v{beta}6 Integrin-A Marker for the Malignant Potential of Epithelial Ovarian Cancer J. Histochem. Cytochem., October 1, 2002; 50(10): 1371 - 1380. [Abstract] [Full Text] [PDF]

				Y. S. Haviv, J. L. Blackwell, A. Kanerva, P. Nagi, V. Krasnykh, I. Dmitriev, M. Wang, S. Naito, X. Lei, A. Hemminki, et al. Adenoviral Gene Therapy for Renal Cancer Requires Retargeting to Alternative Cellular Receptors Cancer Res., August 1, 2002; 62(15): 4273 - 4281. [Abstract] [Full Text] [PDF]

				E. Putz, K. Witter, S. Offner, P. Stosiek, A. Zippelius, J. Johnson, R. Zahn, G. Riethmuller, and K. Pantel Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases Cancer Res., January 1, 1999; 59(1): 241 - 248. [Abstract] [Full Text] [PDF]

				J. Breuss, J Gallo, H. DeLisser, I. Klimanskaya, H. Folkesson, J. Pittet, S. Nishimura, K Aldape, D. Landers, W Carpenter, et al. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling J. Cell Sci., January 6, 1995; 108(6): 2241 - 2251. [Abstract] [PDF]