| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 141, 1237-1246, Copyright © 1992 by American Society for Investigative Pathology
REGULAR ARTICLES |
D Lo, H Quill, L Burkly, B Scott, RD Palmiter and RL Brinster
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.
A line of transgenic mice has been identified with a recessive defect in lymphocyte or granulocyte function, presumably as a result of insertional mutagenesis by the integrated transgene. Transgenic mice homozygous for the transgene integrant showed nearly complete absence of lymphocytes in peripheral lymph nodes and Peyer's patches, a severely diminished thymus medulla, and a greatly enlarged spleen. These animals also developed a syndrome characterized by granulocyte and mononuclear infiltrates in numerous tissues, including skin, liver, and lung, and immunoglobulin deposits in kidney glomeruli. Lung infiltrates were specifically localized around large blood vessels and bronchi, accompanied in some cases by destruction of arterial walls. The light scatter profile of spleen lymphocytes suggested an extremely high percentage of blast cells. Because tissue development and morphology appears to be normal in all other tissues observed, the genetic lesion appears to specifically affect the regulation of lymphocyte or granulocyte activation.
This article has been cited by other articles:
 |
|
 |
|
  P. Castiglioni, D. S. Hall, E. L. Jacovetty, E. Ingulli, and M. Zanetti Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells J. Immunol., April 1, 2008; 180(7): 4956 - 4964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Mineva, T. L. Rothstein, J. A. Meyers, A. Lerner, and G. E. Sonenshein CD40 Ligand-mediated Activation of the de Novo RelB NF-{kappa}B Synthesis Pathway in Transformed B Cells Promotes Rescue from Apoptosis J. Biol. Chem., June 15, 2007; 282(24): 17475 - 17485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gerloni, M. Rizzi, P. Castiglioni, and M. Zanetti T cell immunity using transgenic B lymphocytes PNAS, March 16, 2004; 101(11): 3892 - 3897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Elewaut, R. B. Shaikh, K. J. L. Hammond, H. De Winter, A. J. Leishman, S. Sidobre, O. Turovskaya, T. I. Prigozy, L. Ma, T. A. Banks, et al. NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of V{alpha}14i NKT Cells J. Exp. Med., June 16, 2003; 197(12): 1623 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. ZANETTI, P. CASTIGLIONI, S. SCHOENBERGER, and M. GERLONI The Role of relB in Regulating the Adaptive Immune Response Ann. N.Y. Acad. Sci., April 1, 2003; 987(1): 249 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Castiglioni, C. Lu, D. Lo, M. Croft, P. Langlade-Demoyen, M. Zanetti, and M. Gerloni CD4 T cell priming in dendritic cell-deficient mice Int. Immunol., January 1, 2003; 15(1): 127 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Weih, Z. B. Yilmaz, and F. Weih Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines J. Immunol., August 15, 2001; 167(4): 1909 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xia, S. Chen, Y. Wang, N. Mackman, G. Ku, D. Lo, and L. Feng RelB Modulation of Ikappa Balpha Stability as a Mechanism of Transcription Suppression of Interleukin-1alpha (IL-1alpha ), IL-1beta , and Tumor Necrosis Factor Alpha in Fibroblasts Mol. Cell. Biol., November 1, 1999; 19(11): 7688 - 7696. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
