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American Journal of Pathology, Vol 142, 339-346, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues

R Matsuda, T Takahashi, S Nakamura, Y Sekido, K Nishida, M Seto, T Seito, T Sugiura, Y Ariyoshi and T Takahashi
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan.

The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor that is thought to play an important role in hematopoiesis, spermatogenesis, and melanogenesis. We previously showed that the c-kit messenger RNA is preferentially expressed in small cell lung cancer and that its ligand, stem cell factor, is expressed in a broad spectrum of human cancers. Using anti-c-kit antisera raised against synthetic peptides, in situ localization of the c-kit protein in various human solid tumors as well as in corresponding fetal and adult normal tissues was studied by the ABC method. The results suggest that the c-kit gene products may be involved in the pathogenesis of a very restricted subset of human solid tumors such as small cell lung cancer. Interestingly, nuclear protein immunologically related to c-kit was found in both normal and neoplastic medullary cells of the adrenal gland.

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