| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 142, 359-365, Copyright © 1993 by American Society for Investigative Pathology
REGULAR ARTICLES |
C Pyke, E Ralfkiaer, K Tryggvason and K Dano
Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.
The gene expression of two type IV collagen-degrading enzymes (72-kd and 92-kd type IV collagenases) was investigated in human colon adenocarcinomas by in situ hybridization. In all cases (18 out of 18), messenger RNA for the 72-kd type IV collagenase was present and located in numerous fibroblasts in the stroma surrounding the invasive cancer tissue. In normal-appearing colonic mucosa distant from the cancer tissue, either no expression or only very weak expression of this enzyme was detected. Also the 92-kd type IV collagenase was found in all samples investigated (10 out of 10), exclusively expressed by tissue macrophages. A very strong hybridization signal for messenger RNA for the 92-kd enzyme was found in a subpopulation of tissue macrophages surrounding invading malignant epithelium. In normal- appearing colon tissue, a markedly weaker hybridization signal was observed in macrophages contained in Peyer's patches. No hybridization signals for either of the two type IV collagenases were detected in cancer cells. Together with previous findings on expression of components of the plasminogen activation system, these results indicate that several nonepithelial cell types in the tumor stroma are involved in production of factors involved in extracellular proteolysis during colon cancer invasion.
This article has been cited by other articles:
 |
|
 |
|
  R. R. Nair, J. Solway, and D. D. Boyd Expression Cloning Identifies Transgelin (SM22) as a Novel Repressor of 92-kDa Type IV Collagenase (MMP-9) Expression J. Biol. Chem., September 8, 2006; 281(36): 26424 - 26436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Illemann, N. Bird, A. Majeed, M. Sehested, O. D. Laerum, L. R. Lund, K. Dano, and B. S. Nielsen MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases Mol. Cancer Res., May 1, 2006; 4(5): 293 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Spitz, X. Wu, and G. Mills Integrative Epidemiology: From Risk Assessment to Outcome Prediction J. Clin. Oncol., January 10, 2005; 23(2): 267 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Kirkegaard, A Hansen, E Bruun, and J Brynskov Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease Gut, May 1, 2004; 53(5): 701 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Tester, M. Waltham, S.-J. Oh, S.-N. Bae, M. M. Bills, E. C. Walker, F. G. Kern, W. G. Stetler-Stevenson, M. E. Lippman, and E. W. Thompson Pro-Matrix Metalloproteinase-2 Transfection Increases Orthotopic Primary Growth and Experimental Metastasis of MDA-MB-231 Human Breast Cancer Cells in Nude Mice Cancer Res., January 15, 2004; 64(2): 652 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tahtis, F.-T. Lee, J. M. Wheatley, P. Garin-Chesa, J. E. Park, F. E. Smyth, Y. Obata, E. Stockert, C. M. Hall, L. J. Old, et al. Expression and Targeting of Human Fibroblast Activation Protein in a Human Skin/Severe Combined Immunodeficient Mouse Breast Cancer Xenograft Model Mol. Cancer Ther., August 1, 2003; 2(8): 729 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Yan, H. Wang, Y. Toh, and D. D. Boyd Repression of 92-kDa Type IV Collagenase Expression by MTA1 Is Mediated through Direct Interactions with the Promoter via a Mechanism, Which Is Both Dependent on and Independent of Histone Deacetylation J. Biol. Chem., January 17, 2003; 278(4): 2309 - 2316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Crowther, N. J. Brown, E. T. Bishop, and C. E. Lewis Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors J. Leukoc. Biol., October 1, 2001; 70(4): 478 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Nelson, B. Fingleton, M. L. Rothenberg, and L. M. Matrisian Matrix Metalloproteinases: Biologic Activity and Clinical Implications J. Clin. Oncol., March 1, 2000; 18(5): 1135 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Caudroy, M. Polette, J.-M. Tournier, H. Burlet, B. Toole, S. Zucker, and P. Birembaut Expression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and the Matrix Metalloproteinase-2 in Bronchopulmonary and Breast Lesions J. Histochem. Cytochem., December 1, 1999; 47(12): 1575 - 1580. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. S. Kanwar, K. Ota, Q. Yang, J. Wada, N. Kashihara, Y. Tian, and E. I. Wallner Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis Am J Physiol Renal Physiol, December 1, 1999; 277(6): F934 - F947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Adachi, H Yamamoto, F Itoh, Y Hinoda, Y Okada, and K Imai Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers Gut, August 1, 1999; 45(2): 252 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-S. Zeng, A. M. Cohen, and J. G. Guillem Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis Carcinogenesis, May 1, 1999; 20(5): 749 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Munaut, T. Salonurmi, S. Kontusaari, P. Reponen, T. Morita, J.-M. Foidart, and K. Tryggvason Murine Matrix Metalloproteinase 9 Gene. 5'-UPSTREAM REGION CONTAINS CIS-ACTING ELEMENTS FOR EXPRESSION IN OSTEOCLASTS AND MIGRATING KERATINOCYTES IN TRANSGENIC MICE J. Biol. Chem., February 26, 1999; 274(9): 5588 - 5596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jia, Y. E. Liu, J. Liu, and Y. E. Shi Stimulation of Breast Cancer Invasion and Metastasis by Synuclein {{gamma}} Cancer Res., February 1, 1999; 59(3): 742 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Cox, W P Steward, and K J O'Byrne The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer Thorax, February 1, 1999; 54(2): 169 - 179. [Full Text]
|
|
|
|
 |
|
 T. Iizasa, T. Fujisawa, M. Suzuki, S.-i. Motohashi, K. Yasufuku, T. Yasukawa, M. Baba, and M. Shiba Elevated Levels of Circulating Plasma Matrix Metalloproteinase 9 in Non-Small Cell Lung Cancer Patients Clin. Cancer Res., January 1, 1999; 5(1): 149 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hurskainen, M. Seiki, S. S. Apte, M. Syrjakallio-Ylitalo, T. Sorsa, A. Oikarinen, and H. Autio-Harmainen Production of Membrane-type Matrix Metalloproteinase-1 (MT-MMP-1) in Early Human Placenta: A Possible Role in Placental Implantation? J. Histochem. Cytochem., February 1, 1998; 46(2): 221 - 230. [Abstract] [Full Text]
|
|
|
|
|
|
Y. E. Liu, M. Wang, J. Greene, J. Su, S. Ullrich, H. Li, S. Sheng, P. Alexander, Q. A. Sang, and Y. E. Shi Preparation and Characterization of Recombinant Tissue Inhibitor of Metalloproteinase 4 (TIMP-4) J. Biol. Chem., August 15, 1997; 272(33): 20479 - 20483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Polette, C. Gilles, V. Marchand, M. Lorenzato, B. Toole, J.-M. Tournier, S. Zucker, and P. Birembaut Tumor Collagenase Stimulatory Factor (TCSF) Expression and Localization in Human Lung and Breast Cancers J. Histochem. Cytochem., May 1, 1997; 45(5): 703 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Shofuda, H. Yasumitsu, A. Nishihashi, K. Miki, and K. Miyazaki Expression of Three Membrane-type Matrix Metalloproteinases (MT-MMPs) in Rat Vascular Smooth Muscle Cells and Characterization of MT3-MMPs with and without Transmembrane Domain J. Biol. Chem., April 11, 1997; 272(15): 9749 - 9754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Greene, M. Wang, Y. E. Liu, L. A. Raymond, C. Rosen, and Y. E. Shi Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4 J. Biol. Chem., November 29, 1996; 271(48): 30375 - 30380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lund, J Romer, N Thomasset, H Solberg, C Pyke, M. Bissell, K Dano, and Z Werb Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways Development, January 1, 1996; 122(1): 181 - 193. [Abstract] [PDF]
|
|
|
|
|
|
A. Y. Strongin, I. Collier, G. Bannikov, B. L. Marmer, G. A. Grant, and G. I. Goldberg Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase J. Biol. Chem., March 10, 1995; 270(10): 5331 - 5338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Himelstein, R Canete-Soler, E. Bernhard, and R. Muschel Induction of fibroblast 92 kDa gelatinase/type IV collagenase expression by direct contact with metastatic tumor cells J. Cell Sci., January 2, 1994; 107(2): 477 - 486. [Abstract] [PDF]
|
|
|
|
|
|
U. T. Shankavaram, W.-C. Lai, S. Netzel-Arnett, P. R. Mangan, J. A. Ardans, N. Caterina, W. G. Stetler-Stevenson, H. Birkedal-Hansen, and L. M. Wahl Monocyte Membrane Type 1-Matrix Metalloproteinase. PROSTAGLANDIN-DEPENDENT REGULATION AND ROLE IN METALLOPROTEINASE-2 ACTIVATION J. Biol. Chem., May 25, 2001; 276(22): 19027 - 19032. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
