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American Journal of Pathology, Vol 142, 1866-1875, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Localization of interferon-gamma and Ia-antigen in T cell line-mediated experimental autoimmune encephalomyelitis

G Stoll, S Muller, B Schmidt, P van der Meide, S Jung, KV Toyka and HP Hartung
Department of Neurology, Heinrich-Heine-Universitat, Dusseldorf, Germany.

This study reports the cellular localization of interferon-gamma (IFN- gamma) and MHC class II antigen (Ia) in the spinal cord of rats with experimental autoimmune encephalomyelitis induced by adoptive transfer of myelin basic protein-specific T cells. Numerous IFN-gamma-positive cells, stained with two different monoclonal antibodies against IFN- gamma, were present from days 3 to 7 after cell transfer. Their number was greatly reduced on day 10. A subpopulation of T cells was IFN-gamma positive. Moreover, a large number of ED1-positive macrophages contained IFN-gamma immunoreactivity. The transient presence of immune cells containing IFN-gamma immunoreactivity in experimental autoimmune encephalomyelitis suggests a pathogenic role of this cytokine in immune- mediated demyelination of the central nervous system.


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Copyright © 1993 by the American Society for Investigative Pathology.