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American Journal of Pathology, Vol 143, 121-129, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension

MD Botney, MJ Liptay, LR Kaiser, JD Cooper, WC Parks and RP Mecham
Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110.

Immunohistochemistry was performed on lung tissue obtained from patients with severe unexplained pulmonary hypertension using an antibody to the amino-terminal end of the procollagen type I propeptide. This antibody identifies newly synthesized alpha I(I) procollagen before cleavage of the amino-terminal propeptide following secretion and, therefore, can identify sites of active collagen deposition. Procollagen was detected in the media, media and neointima, or neointima alone of a large number of small muscular arteries from hypertensive lungs. Normal adult lungs were negative. Neointimal cells in remodeled small muscular arteries stained positively for alpha- smooth muscle actin and desmin consistent with a smooth muscle lineage. These data suggest smooth muscle-like cells in small muscular arteries are actively synthesizing collagen in patients with severe unexplained pulmonary hypertension.

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