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American Journal of Pathology, Vol 143, 191-198, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Expression of intercellular adhesion molecule-1 on transitional cell cancer. Possible significance in immunity against tumor cells

Y Tomita, H Watanabe, H Kobayashi, T Nishiyama, S Tsuji, K Imai, T Abo, M Fujiwara and S Sato
Department of Urology, Niigata University School of Medicine, Japan.

Immunohistochemical examination demonstrated expression of intercellular adhesion molecule-1 (ICAM-1) on 17 of 44 transitional cell cancers (TCCs) but not on normal transitional cells. ICAM-1 was frequently expressed in higher stage tumors, especially in those with abundant immune cells scattered within tumor. Analysis of infiltrating immune cells showed that they were composed mainly of T lymphocytes and a smaller number of macrophages bearing the lymphocyte function- associated antigen-1 (LFA-1). Expression of ICAM-1 on transitional cell cancer cell lines was augmented by in vitro treatment with interferon- gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Furthermore, Northern blot analysis revealed higher quantities of a 3.3- kb RNA in T24 cells exposed to interferon-gamma or tumor necrosis factor-alpha. These results suggest that the expression of ICAM-1 on transitional cell cancers might be modified by cytokines produced by infiltrating immune cells, which might facilitate immune responses against cancer cells.


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Copyright © 1993 by the American Society for Investigative Pathology.