help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Russell, G. J.
Right arrow Articles by Bhan, A. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Russell, G. J.
Right arrow Articles by Bhan, A. K.

American Journal of Pathology, Vol 143, 350-354, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Cytotoxic potential of intraepithelial lymphocytes (IELs). Presence of TIA-1, the cytolytic granule-associated protein, in human IELs in normal and diseased intestine

GJ Russell, C Nagler-Anderson, P Anderson and AK Bhan
Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts.

Human intestinal intraepithelial lymphocytes (IELs) have phenotypic characteristics of cytotoxic T cells, yet a cytotoxic function has not been demonstrated in redirected lysis assays. A monoclonal antibody that reacts with a cytotoxic granule-associated protein, TIA-1, was used in this study to identify this protein in many, but not all, IELs of normal human proximal small intestine. Furthermore, in active celiac disease, in which the number of IELs is significantly increased, a corresponding increase in the number of TIA-1 cells was found. These results indicate that whereas cytotoxicity of human IELs has been difficult to demonstrate, they contain at least one of the proteins associated with cytotoxicity, and a failure to demonstrate this function may be related to the in vitro assay system used.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
N. Corazza, S. Muller, T. Brunner, D. Kagi, and C. Mueller
Differential Contribution of Fas- and Perforin-Mediated Mechanisms to the Cell-Mediated Cytotoxic Activity of Naive and In Vivo-Primed Intestinal Intraepithelial Lymphocytes
J. Immunol., January 1, 2000; 164(1): 398 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. H. Vermeer, F. A.M.J. Geelen, J. A. Kummer, C. J.L.M. Meijer, and R. Willemze
Expression of Cytotoxic Proteins by Neoplastic T Cells in Mycosis Fungoides Increases with Progression from Plaque Stage to Tumor Stage Disease
Am. J. Pathol., April 1, 1999; 154(4): 1203 - 1210.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American Society for Investigative Pathology.