| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 143, 685-698, Copyright © 1993 by American Society for Investigative Pathology
REGULAR ARTICLES |
A Hoorens, NR Lemoine, E McLellan, T Morohoshi, T Kamisawa, PU Heitz, B Stamm, J Ruschoff, B Wiedenmann and G Kloppel
Department of Pathology, Academic Hospital Jette, Free University of Brussels, Belgium.
In a series of 22 pancreatic acinar cell carcinomas, including two acinar cystadenocarcinomas, cellular differentiation was analyzed by immunocytochemistry and electron microscopy. In addition, overexpression of p53 protein and Ki-ras codon 12 mutation was studied. Four of the 20 noncystic acinar cell carcinomas showed a pure acinar pattern, nine an acinar-solid, and seven a solid pattern. All tumors stained for at least one of the following pancreatic acinar markers: trypsin (21 of 22), lipase (19 of 22), chymotrypsin (13 of 22), phospholipase A2 (nine of 22), and pancreatic stone protein (19 of 22). One-third of the tumors expressed neuroendocrine markers (synaptophysin, eight of 22; chromogranin A, six of 21) and duct cell markers (CA19.9, nine of 21; B72.3, six of 21). Cellular coexpression of trypsin and synaptophysin was demonstrated in one tumor. Electron microscopy revealed zymogen granules (nine of nine). In only one of 16 tumors a Ki-ras mutation at codon 12 was found, whereas in none of 19 tumors could overexpression of p53 protein be demonstrated. The results suggest that acinar cell carcinomas show obvious capacity to differentiate into several directions, but nevertheless constitute an entity different from ductal adenocarcinomas or endocrine tumors.
This article has been cited by other articles:
 |
|
 |
|
  E. M. Chung, M. D. Travis, and R. M. Conran From the Archives of the AFIP: Pancreatic Tumors in Children: Radiologic-Pathologic Correlation. RadioGraphics, July 1, 2006; 26(4): 1211 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Hansel, A. Rahman, S. Wehner, V. Herzog, C. J. Yeo, and A. Maitra Increased Expression and Processing of the Alzheimer Amyloid Precursor Protein in Pancreatic Cancer May Influence Cellular Proliferation Cancer Res., November 1, 2003; 63(21): 7032 - 7037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Tamm, P. M. Silverman, C. Charnsangavej, and D. B. Evans Diagnosis, Staging, and Surveillance of Pancreatic Cancer Am. J. Roentgenol., May 1, 2003; 180(5): 1311 - 1323. [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Holen, D. S. Klimstra, A. Hummer, M. Gonen, K. Conlon, M. Brennan, and L. B. Saltz Clinical Characteristics and Outcomes From an Institutional Series of Acinar Cell Carcinoma of the Pancreas and Related Tumors J. Clin. Oncol., December 15, 2002; 20(24): 4673 - 4678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ashley and G. Y. Lauwers Case 37-2002 - A 69-Year-Old Man with Painful Cutaneous Nodules, Elevated Lipase Levels, and Abnormal Results on Abdominal Scanning N. Engl. J. Med., November 28, 2002; 347(22): 1783 - 1791. [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Abraham, D. S. Klimstra, R. E. Wilentz, C. J. Yeo, K. Conlon, M. Brennan, J. L. Cameron, T.-T. Wu, and R. H. Hruban Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor {beta}-catenin Mutations Am. J. Pathol., April 1, 2002; 160(4): 1361 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Abraham, T.-T. Wu, R. H. Hruban, J.-H. Lee, C. J. Yeo, K. Conlon, M. Brennan, J. L. Cameron, and D. S. Klimstra Genetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma : Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/{beta}-Catenin Pathway Am. J. Pathol., March 1, 2002; 160(3): 953 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. LONGNECKER Molecular Pathology of Invasive Carcinoma Ann. N.Y. Acad. Sci., June 30, 1999; 880(1): 74 - 82. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
