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American Journal of Pathology, Vol 143, 1040-1043, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

ICAM-3 expression on endothelium in lymphoid malignancy

I Doussis-Anagnostopoulou, L Kaklamanis, J Cordell, M Jones, H Turley, K Pulford, D Simmons, D Mason and K Gatter
Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom.

Intercellular adhesion molecule-3 (ICAM-3), the third receptor for lymphocyte function-associated antigen molecule-1 and a new member of the immunoglobulin superfamily has been recently characterized using specific monoclonal antibodies. In the present study, we show immunocytochemically that ICAM-3 is present on T and B cells in the mantle zones and on a subpopulation of follicular center cells in reactive lymph nodes and only occasionally in endothelium. In 52 cases of Hodgkin's disease, ICAM-3, although present on the majority of the reactive lymphoid cells, was absent from the Reed-Sternberg cells and their variants. However, in 28 cases (54%), there was prominent endothelial staining in small vessels. Similar findings were noted in 16 out of 49 cases (33%) of non-Hodgkin's lymphomas. This finding suggests that analogous to ICAM-1 and ICAM-2, ICAM-3 expression can be induced on endothelial cells in lymphoid neoplasms, probably by an as yet unidentified cytokine-mediated mechanism.


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Copyright © 1993 by the American Society for Investigative Pathology.