This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oda, K. Articles by Nakajima, N. Search for Related Content PubMed PubMed Citation Articles by Oda, K. Articles by Nakajima, N.

American Journal of Pathology, Vol 143, 1063-1071, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma

K Oda, J Tamaru, T Takenouchi, A Mikata, M Nunomura, N Saitoh, H Sarashina and N Nakajima
First Department of Surgery, School of Medicine, Chiba University, Japan.

Epstein-Barr virus (EBV) has been detected in lymphoepithelioma of nasopharynx and lymphoepitheliomalike carcinomas in various organs. To clarify the association of EBV with gastric carcinoma with lymphoid stroma, which often resembles lymphoepithelioma, the authors examined 22 such cases by polymerase chain reaction and in situ hybridization techniques. In 18 informative cases, EBV DNA was detected by polymerase chain reaction in 14 (77.8%) cases, including lymph node metastases. EBV RNA was detected within the nuclei of carcinoma cells by in situ hybridization in all cases that were positive by polymerase chain reaction. Infiltrating lymphocytes and normal epithelia adjacent to carcinoma were EBV-negative. Southern blot analysis indicated clonal proliferation of tumor cells and episomal form of EBV. These findings suggest that EBV infection occurs before transformation and may be related to oncogenesis of EBV-associated gastric carcinoma.

This article has been cited by other articles:

				L.-Y. Li, M.-Y. Liu, H.-M. Shih, C.-H. Tsai, and J.-Y. Chen Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. J. Gen. Virol., October 1, 2006; 87(Pt 10): 2869 - 2878. [Abstract] [Full Text] [PDF]

				K. Kurosu, M. D. Weiden, Y. Takiguchi, W. N. Rom, N. Yumoto, J. Jaishree, K. Nakata, Y. Kasahara, N. Tanabe, K. Tatsumi, et al. BCL-6 Mutations in Pulmonary Lymphoproliferative Disorders: Demonstration of an Aberrant Immunological Reaction in HIV-Related Lymphoid Interstitial Pneumonia J. Immunol., June 1, 2004; 172(11): 7116 - 7122. [Abstract] [Full Text] [PDF]

				M. P. Thompson and R. Kurzrock Epstein-Barr Virus and Cancer Clin. Cancer Res., February 1, 2004; 10(3): 803 - 821. [Abstract] [Full Text] [PDF]

				Q N Vo, J Geradts, M L Gulley, D A Boudreau, J C Bravo, and B G Schneider Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation J. Clin. Pathol., September 1, 2002; 55(9): 669 - 675. [Abstract] [Full Text] [PDF]

				R. K. C. Ngan, T. T. C. Yip, W.-W. Cheng, J. K. C. Chan, W. C. S. Cho, V. W. S. Ma, K.-K. Wan, S.-K. Au, C.-K. Law, and W.-H. Lau Circulating Epstein-Barr Virus DNA in Serum of Patients with Lymphoepithelioma-like Carcinoma of the Lung: A Potential Surrogate Marker for Monitoring Disease Clin. Cancer Res., April 1, 2002; 8(4): 986 - 994. [Abstract] [Full Text] [PDF]

				K. KUROSU, N. YUMOTO, W. N. ROM, Y. TAKIGUCHI, J. JAISHREE, K. NAKATA, K. TATSUMI, A. MIKATA, T. KURIYAMA, and M. D. WEIDEN Oligoclonal T Cell Expansions in Pulmonary Lymphoproliferative Disorders . Demonstration of the Frequent Occurrence of Oligoclonal T Cells in Human Immunodeficiency Virus-Related Lymphoid Interstitial Pneumonia Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 254 - 259. [Abstract] [Full Text] [PDF]

				K Takada Epstein-Barr virus and gastric carcinoma Mol. Pathol., October 1, 2000; 53(5): 255 - 261. [Abstract] [Full Text]

				J. Wang, A. Noffsinger, G. Stemmermann, and C. Fenoglio-Preiser Esophageal Squamous Cell Carcinomas Arising in Patients from a High-Risk Area of North China Lack An Association with Epstein-Barr Virus Cancer Epidemiol. Biomarkers Prev., December 1, 1999; 8(12): 1111 - 1114. [Abstract] [Full Text]

				C. T.K.-H. Stadtlander and J. W. waterbor Molecular epidemiology, pathogenesis and prevention of gastric cancer Carcinogenesis, December 1, 1999; 20(12): 2195 - 2208. [Abstract] [Full Text] [PDF]

				G. D. Clark, Yoke Sun Lee, K.-W. Min, and S. T. Dunn Epstein-Barr Virus in Gastric Carcinomas from Singapore International Journal of Surgical Pathology, January 1, 1996; 4(3): 149 - 158. [Abstract] [PDF]

				L.-Y. Li, H.-M. Shih, M.-Y. Liu, and J.-Y. Chen The Cellular Protein PRA1 Modulates the Anti-apoptotic Activity of Epstein-Barr Virus BHRF1, a Homologue of Bcl-2, through Direct Interaction J. Biol. Chem., July 13, 2001; 276(29): 27354 - 27362. [Abstract] [Full Text] [PDF]