help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tracy, T. F.
Right arrow Articles by Lagunoff, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tracy, T. F., Jr
Right arrow Articles by Lagunoff, D.

American Journal of Pathology, Vol 143, 1574-1578, Copyright © 1993 by American Society for Investigative Pathology

REGULAR ARTICLES

Somatostatin analogue (octreotide) inhibits bile duct epithelial cell proliferation and fibrosis after extrahepatic biliary obstruction

TF Tracy Jr, AJ Tector, ME Goerke, S Kitchen and D Lagunoff
Department of Surgery, University School of Medicine, St. Louis, Missouri.

Extrahepatic biliary obstruction leads to bile duct epithelial cell proliferation. Somatostatin and its analogue, octreotide, have been shown to inhibit DNA synthesis and proliferation in hepatocytes. We investigated the effect of octreotide on the biliary epithelial cell proliferative responses to biliary obstruction. Male Sprague-Dawley rats underwent common bile duct ligation and subcutaneous injection of either saline or octreotide (6 micrograms/kg) twice daily for 7 days. Morphometric analysis of hepatocytes, bile duct epithelial cells, and periportal connective tissue was performed by computerized point counting. Hepatocyte volume was preserved with octreotide treatment, which also significantly decreased bile duct proliferation and periportal extracellular matrix deposition in response to biliary obstruction compared with saline treated, duct-ligated animals. These results indicate that octreotide prevents the morphological changes that accompany extrahepatic biliary obstruction.


This article has been cited by other articles:


Home page
 ThoraxHome page
R Borie, A Fabre, F Prost, J Marchal-Somme, R Lebtahi, S Marchand-Adam, M Aubier, P Soler, and B Crestani
Activation of somatostatin receptors attenuates pulmonary fibrosis
Thorax, March 1, 2008; 63(3): 251 - 258.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. Lebtahi, S. Moreau, S. Marchand-Adam, M.-P. Debray, M. Brauner, P. Soler, J. Marchal, O. Raguin, A. Gruaz-Guyon, J.-C. Reubi, et al.
Increased Uptake of 111In-Octreotide in Idiopathic Pulmonary Fibrosis
J. Nucl. Med., August 1, 2006; 47(8): 1281 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A.-Y. Gong, P. S. Tietz, M. A. Muff, P. L. Splinter, R. C. Huebert, M. Z. Strowski, X.-M. Chen, and N. F. LaRusso
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes
Am J Physiol Cell Physiol, May 1, 2003; 284(5): C1205 - C1214.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. S. Glaser, R. E. D. Rodgers, J. L. Phinizy, W. E. Robertson, J. Lasater, A. Caligiuri, Z. Tretjak, G. D. Lesage, and G. Alpini
Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1061 - G1070.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American Society for Investigative Pathology.