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American Journal of Pathology, Vol 144, 51-59, Copyright © 1994 by American Society for Investigative Pathology

REGULAR ARTICLES

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor

YM Zhang, S Bachmann, C Hemmer, J van Lunzen, A von Stemm, P Kern, M Dietrich, R Ziegler, R Waldherr and PP Nawroth
Department of Medicine, Pathology and Anatomy, University of Heidelberg, Germany.

We studied seven cases of Kaposi's sarcomas (KS) obtained from patients with AIDS and one KS from a patient without HIV infection. Antigen expression was studied by immunocytochemistry and mRNA expression by in situ hybridisation. The markers tested were endothelial leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. In all tumors (AIDS and non-AIDS associated) these markers reacted positive, indicating transcription and translation of these genes in KS. The synthesis and expression of tissue factor and thrombomodulin suggests that KS is a tumor that has tissue factor-mediated thrombin formation under the control of thrombomodulin. The expression of thrombomodulin and endothelial leukocyte adhesion molecule-1 provides evidence for the vascular origin of KS.

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