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American Journal of Pathology, Vol 144, 209-214, Copyright © 1994 by American Society for Investigative Pathology

REVIEWS

Role of human immunodeficiency virus infection in the pathogenesis of human papillomavirus-associated cervical neoplasia

L Braun
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912.

Although many basic questions about the relationship between HIV and HPV infection remain unresolved, epidemiological studies have consistently shown a strong association between HIV infection and the development of HPV-related squamous intraepithelial neoplasia. This work indicates that HIV infection may promote the clinical manifestation of subclinical or latent HPV infection. Recent technical advances localizing virus DNA and gene products in situ will provide new avenues for investigation, allowing us to go beyond correlations and to clarify the mechanisms of interaction between the two viruses in individual patients. With improved antiretroviral therapy and prophylaxis for HIV-associated opportunistic infection and prolonged survival of women with HIV, HPV infection and its most serious consequence, cervical cancer, are likely to assume greater significance in the clinical management of HIV-infected women throughout the world. A better understanding of the role of HIV in promoting the clinical manifestation of HPV infection will be essential to the control of this disease.

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