This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Paus, R. Articles by Czarnetzki, B. M. Search for Related Content PubMed PubMed Citation Articles by Paus, R. Articles by Czarnetzki, B. M.

American Journal of Pathology, Vol 144, 719-734, Copyright © 1994 by American Society for Investigative Pathology

REGULAR ARTICLES

Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone

R Paus, B Handjiski, S Eichmuller and BM Czarnetzki
Department of Dermatology, University Hospital Rudolf Virchow, Freie Universitat Berlin, Germany.

We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy- induced alopecia and for developing anti-alopecia drugs. One injection of CYP to mice with all back skin follicles in anagen VI induces severe alopecia that strikingly reproduces the follicle response, recovery, and histopathology seen in human CYP-IA. CYP dose-dependently induces abnormal follicular melanogenesis and dystrophic anagen or, in more severely damaged follicles, dystrophic catagen. Both dystrophy forms are followed by an extremely shortened telogen phase, but differ in the associated hair loss and in recovery patterns, which determines hair regrowth. This follicular response to CYP can be manipulated pharmacologically: systemic cyclosporine A shifts it toward a mild form of dystrophic anagen, thus retarding CYP-IA and prolonging "primary recovery". Topical dexamethasone, in contrast, forces follicles into dystrophic catagen, which augments CYP-IA, but accelerates the regrowth of normally pigmented hair ("secondary recovery").

This article has been cited by other articles:

				E. Bodo, D. J. Tobin, Y. Kamenisch, T. Biro, M. Berneburg, W. Funk, and R. Paus Dissecting the Impact of Chemotherapy on the Human Hair Follicle: A Pragmatic in Vitro Assay for Studying the Pathogenesis and Potential Management of Hair Follicle Dystrophy Am. J. Pathol., October 1, 2007; 171(4): 1153 - 1167. [Abstract] [Full Text] [PDF]

				U. Ohnemus, M. Uenalan, J. Inzunza, J.-A. Gustafsson, and R. Paus The Hair Follicle as an Estrogen Target and Source Endocr. Rev., October 1, 2006; 27(6): 677 - 706. [Abstract] [Full Text] [PDF]

				E. Zcharia, D. Philp, E. Edovitsky, H. Aingorn, S. Metzger, H. K. Kleinman, I. Vlodavsky, and M. Elkin Heparanase Regulates Murine Hair Growth Am. J. Pathol., April 1, 2005; 166(4): 999 - 1008. [Abstract] [Full Text] [PDF]

				U. Ohnemus, M. Uenalan, F. Conrad, B. Handjiski, L. Mecklenburg, M. Nakamura, J. Inzunza, J.-A. Gustafsson, and R. Paus Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-{alpha} Is Checked by ER{beta} Signaling Endocrinology, March 1, 2005; 146(3): 1214 - 1225. [Abstract] [Full Text] [PDF]

				A. A. Sharov, F. Siebenhaar, T. Y. Sharova, N. V. Botchkareva, B. A. Gilchrest, and V. A. Botchkarev Fas Signaling Is Involved in the Control of Hair Follicle Response to Chemotherapy Cancer Res., September 1, 2004; 64(17): 6266 - 6270. [Abstract] [Full Text] [PDF]

				N. Sato, P. L. Leopold, and R. G. Crystal Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia J Natl Cancer Inst, December 19, 2001; 93(24): 1858 - 1864. [Abstract] [Full Text] [PDF]

				V. A. Botchkarev, E. A. Komarova, F. Siebenhaar, N. V. Botchkareva, A. A. Sharov, P. G. Komarov, M. Maurer, A. V. Gudkov, and B. A. Gilchrest p53 Involvement in the Control of Murine Hair Follicle Regression Am. J. Pathol., June 1, 2001; 158(6): 1913 - 1919. [Abstract] [Full Text] [PDF]

				K. S. Stenn and R. Paus Controls of Hair Follicle Cycling Physiol Rev, January 1, 2001; 81(1): 449 - 494. [Abstract] [Full Text] [PDF]

				V. A. BOTCHKAREV, N. V. BOTCHKAREVA, K. M. ALBERS, L.-H. CHEN, P. WELKER, and R. PAUS A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression FASEB J, October 1, 2000; 14(13): 1931 - 1942. [Abstract] [Full Text]

				V. A. Botchkarev, E. A. Komarova, F. Siebenhaar, N. V. Botchkareva, P. G. Komarov, M. Maurer, B. A. Gilchrest, and A. V. Gudkov p53 Is Essential for Chemotherapy-induced Hair Loss Cancer Res., September 1, 2000; 60(18): 5002 - 5006. [Abstract] [Full Text]

				K. FOITZIK, G. LINDNER, S. MUELLER-ROEVER, M. MAURER, N. BOTCHKAREVA, V. BOTCHKAREV, B. HANDJISKI, M. METZ, T. HIBINO, T. SOMA, et al. Control of murine hair follicle regression (catagen) by TGF-{beta}1 in vivo FASEB J, April 1, 2000; 14(5): 752 - 760. [Abstract] [Full Text]

				S. Muller-Rover, H. Rossiter, R. Paus, B. Handjiski, E. M. J. Peters, J.-E. Murphy, L. Mecklenburg, and T. S. Kupper Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia Am. J. Pathol., April 1, 2000; 156(4): 1395 - 1405. [Abstract] [Full Text] [PDF]

				V. A. Botchkarev, P. Welker, K. M. Albers, N. V. Botchkareva, M. Metz, G. R. Lewin, S. Bulfone-Paus, E. M. J. Peters, G. Lindner, and R. Paus A New Role for Neurotrophin-3 : Involvement in the Regulation of Hair Follicle Regression(Catagen) Am. J. Pathol., September 1, 1998; 153(3): 785 - 799. [Abstract] [Full Text] [PDF]