| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 144, 952-961, Copyright © 1994 by American Society for Investigative Pathology
REGULAR ARTICLES |
RR Johnson-Tidey, JL McGregor, PR Taylor and RN Poston
Department of Experimental Pathology, UMDS, Guys Hospital, London, United Kingdom.
P-selectin (GMP-140) is an adhesion molecule present within endothelial cells that is rapidly translocated to the cell membrane upon activation, where it mediates endothelial-leukocyte interactions. Immunohistochemical analysis of human atherosclerotic plaques has shown strong expression of P-selectin by the endothelium overlying active atherosclerotic plaques. P-selectin is not, however, detected in normal arterial endothelium or in endothelium overlying inactive fibrous plaques. Color image analysis was used to quantitate the degree of P- selectin expression in the endothelium and demonstrates a statistically significant increase in P-selectin expression by atherosclerotic endothelial cells. Double immunofluorescence shows that some of this P- selectin is expressed on the luminal surface of the endothelial cells. Previous work has demonstrated a significant up-regulation in the expression of the intercellular adhesion molecule-1 in atherosclerotic endothelium and a study on the expression of intercellular adhesion molecule-1 and P-selectin in atherosclerosis shows a highly positive correlation. These results suggest that the selective and cooperative expression of P-selectin and intercellular adhesion molecule-1 may be involved in the recruitment of monocytes into sites of atherosclerosis.
This article has been cited by other articles:
 |
|
 |
|
  E. Shagdarsuren, K. Bidzhekov, Y. Djalali-Talab, E. A. Liehn, M. Hristov, R. A. Matthijsen, W. A. Buurman, A. Zernecke, and C. Weber C1-Esterase Inhibitor Protects Against Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice Circulation, January 1, 2008; 117(1): 70 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N.-T. Luu, J. Madden, P. C. Calder, R. F. Grimble, C. P. Shearman, T. Chan, N. Dastur, W. M. Howell, G. E. Rainger, and G. B. Nash Dietary Supplementation with Fish Oil Modifies the Ability of Human Monocytes to Induce an Inflammatory Response J. Nutr., December 1, 2007; 137(12): 2769 - 2774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Galkina and K. Ley Vascular Adhesion Molecules in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., November 1, 2007; 27(11): 2292 - 2301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Burns and N. DePaola Flow-conditioned HUVECs support clustered leukocyte adhesion by coexpressing ICAM-1 and E-selectin Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H194 - H204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Blann, S. K. Nadar, and G. Y.H. Lip The adhesion molecule P-selectin and cardiovascular disease Eur. Heart J., December 2, 2003; 24(24): 2166 - 2179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, Y.-J. Kim, C. Mantel, and H. E. Broxmeyer P-Selectin Enhances Generation of CD14+CD16+ Dendritic-Like Cells and Inhibits Macrophage Maturation from Human Peripheral Blood Monocytes J. Immunol., July 15, 2003; 171(2): 669 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wang, C. W.H. Woo, F. L. Sung, Y. L. Siow, and K. O Increased Monocyte Adhesion to Aortic Endothelium in Rats With Hyperhomocysteinemia: Role of Chemokine and Adhesion Molecules Arterioscler. Thromb. Vasc. Biol., November 1, 2002; 22(11): 1777 - 1783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Rosenfeld Leukocyte Recruitment Into Developing Atherosclerotic Lesions: The Complex Interaction Between Multiple Molecules Keeps Getting More Complex Arterioscler. Thromb. Vasc. Biol., March 1, 2002; 22(3): 361 - 363. [Full Text] [PDF]
|
|
|
|
 |
|
 G.F. Gensini and B. Dilaghi The unstable plaque Eur. Heart J. Suppl., March 1, 2002; 4(suppl_B): B22 - B27. [Abstract] [PDF]
|
|
|
|
|
|
S. C. Barbaux, S. Blankenberg, H. J. Rupprecht, C. Francomme, C. Bickel, G. Hafner, V. Nicaud, J. Meyer, F. Cambien, and L. Tiret Association Between P-Selectin Gene Polymorphisms and Soluble P-Selectin Levels and Their Relation to Coronary Artery Disease Arterioscler. Thromb. Vasc. Biol., October 1, 2001; 21(10): 1668 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. G. Laszik, X. J. Zhou, G. L. Ferrell, F. G. Silva, and C. T. Esmon Down-Regulation of Endothelial Expression of Endothelial Cell Protein C Receptor and Thrombomodulin in Coronary Atherosclerosis Am. J. Pathol., September 1, 2001; 159(3): 797 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Skilbeck, S. M. Westwood, P. G. Walker, T. David, and G. B. Nash Population of the Vessel Wall by Leukocytes Binding to P-Selectin in a Model of Disturbed Arterial Flow Arterioscler. Thromb. Vasc. Biol., August 1, 2001; 21(8): 1294 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Rainger and G. B. Nash Cellular Pathology of Atherosclerosis : Smooth Muscle Cells Prime Cocultured Endothelial Cells for Enhanced Leukocyte Adhesion Circ. Res., March 30, 2001; 88(6): 615 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Ridker, J. E. Buring, and N. Rifai Soluble P-Selectin and the Risk of Future Cardiovascular Events Circulation, January 30, 2001; 103(4): 491 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Bourdillon, R. N. Poston, C. Covacho, E. Chignier, G. Bricca, and J. L. McGregor ICAM-1 Deficiency Reduces Atherosclerotic Lesions in Double-Knockout Mice (ApoE-/-/ICAM-1-/-) Fed a Fat or a Chow Diet Arterioscler. Thromb. Vasc. Biol., December 1, 2000; 20(12): 2630 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Zibara, E. Chignier, C. Covacho, R. Poston, G. Canard, P. Hardy, and J. McGregor Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet-Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E-Deficient Compared With Wild-Type Mice Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2288 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Yipp, S. Anand, T. Schollaardt, K. D. Patel, S. Looareesuwan, and M. Ho Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow Blood, September 15, 2000; 96(6): 2292 - 2298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Calderon, S. D. Gertz, I. J. Sarembock, J. A. Berliner, J. T. Fallon, M. B. Taubman, and J. W. Berman Induction of IG9 Monocyte Adhesion Molecule Expression in Smooth Muscle and Endothelial Cells After Balloon Arterial Injury in Cholesterol-Fed Rabbits Arterioscler. Thromb. Vasc. Biol., May 1, 2000; 20(5): 1293 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Eriksson, J. Werr, Y. Guo, P. Thoren, and L. Lindbom Direct Observations In Vivo on the Role of Endothelial Selectins and {alpha}4 Integrin in Cytokine-Induced Leukocyte-Endothelium Interactions in the Mouse Aorta Circ. Res., March 17, 2000; 86(5): 526 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Stocker, K. L. Sugars, O. A. Harari, R. C. Landis, B. J. Morley, and D. O. Haskard TNF-{alpha}, IL-4, and IFN-{gamma} Regulate Differential Expression of P- and E-Selectin Expression by Porcine Aortic Endothelial Cells J. Immunol., March 15, 2000; 164(6): 3309 - 3315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Golledge, R. M. Greenhalgh, and A. H. Davies The Symptomatic Carotid Plaque Stroke, March 1, 2000; 31(3): 774 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Collins, R. Velji, N. V. Guevara, M. J. Hicks, L. Chan, and A. L. Beaudet P-Selectin or Intercellular Adhesion Molecule (ICAM)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E-deficient Mice J. Exp. Med., January 3, 2000; 191(1): 189 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yao, H. Setiadi, L. Xia, Z. Laszik, F. B. Taylor, and R. P. McEver Divergent Inducible Expression of P-Selectin and E-Selectin in Mice and Primates Blood, December 1, 1999; 94(11): 3820 - 3828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Blann, F. Li-Saw-Hee, G. Y.H. Lip, T. Minamino, M. Kitakaze, S. Sanada, H. Asanuma, T. Kurotobi, Y. Koretsune, M. Fukunami, et al. Increased Membrane and Soluble P-Selectin in Atrial Fibrillation • Response Circulation, October 26, 1999; 100 (17): e86 - e87. [Full Text] [PDF]
|
|
|
|
|
|
K. Fassbender, T. Bertsch, O. Mielke, F. Muhlhauser, and M. Hennerici Adhesion Molecules in Cerebrovascular Diseases : Evidence for an Inflammatory Endothelial Activation in Cerebral Large- and Small-Vessel Disease Stroke, August 1, 1999; 30(8): 1647 - 1650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M Dart and J. P.F Chin-Dusting Lipids and the endothelium Cardiovasc Res, August 1, 1999; 43(2): 308 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yago, M. Tsukuda, and M. Minami P-Selectin Binding Promotes the Adhesion of Monocytes to VCAM-1 Under Flow Conditions J. Immunol., July 1, 1999; 163(1): 367 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kataoka, N. Kume, S. Miyamoto, M. Minami, H. Moriwaki, T. Murase, T. Sawamura, T. Masaki, N. Hashimoto, and T. Kita Expression of Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 in Human Atherosclerotic Lesions Circulation, June 22, 1999; 99(24): 3110 - 3117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Ramos, Y. Huo, U. Jung, S. Ghosh, D. R. Manka, I. J. Sarembock, and K. Ley Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice Circ. Res., June 11, 1999; 84(11): 1237 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Lefer and D. N. Granger Monocyte Rolling in Early Atherogenesis : Vital Role in Lesion Development Circ. Res., June 11, 1999; 84(11): 1353 - 1355. [Full Text] [PDF]
|
|
|
|
|
|
Y. Khew-Goodall, C. Wadham, B. N. Stein, J. R. Gamble, and M. A. Vadas Stat6 Activation Is Essential for Interleukin-4 Induction of P-Selectin Transcription in Human Umbilical Vein Endothelial Cells Arterioscler. Thromb. Vasc. Biol., June 1, 1999; 19(6): 1421 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D Blann, G. Y.H. Lip, R. Fijnheer, G. Davi, A. Mezzetti, T. Antidormi, F. Cuccurullo, A. Procopio, S. Iacobelli, T. Bucciarelli, et al. Significance of Soluble P-Selectin, Von Willebrand Factor, and Other Adhesion Molecules in Hypercholesterolemia and Peripheral Artery Disease • Response Circulation, May 11, 1999; 99 (18): 2476 - 2479. [Full Text] [PDF]
|
|
|
|
|
|
G. W. Cockerill, J. Saklatvala, S. H. Ridley, H. Yarwood, N. E. Miller, B. Oral, S. Nithyanathan, G. Taylor, and D. O. Haskard High-Density Lipoproteins Differentially Modulate Cytokine-Induced Expression of E-Selectin and Cyclooxygenase-2 Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 910 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Davi, M. Romano, A. Mezzetti, A. Procopio, S. Iacobelli, T. Antidormi, T. Bucciarelli, P. Alessandrini, F. Cuccurullo, and G. B. Bon Increased Levels of Soluble P-Selectin in Hypercholesterolemic Patients Circulation, March 17, 1998; 97(10): 953 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xia, J. Pan, L. Yao, and R. P. McEver A Proteasome Inhibitor, an Antioxidant, or a Salicylate, but not a Glucocorticoid, Blocks Constitutive and Cytokine-Inducible Expression of P-Selectin in Human Endothelial Cells Blood, March 1, 1998; 91(5): 1625 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, M. Poon, and J. T. Willerson Learning From the Transgenic Mouse : Endothelium, Adhesive Molecules, and Neointimal Formation Circulation, January 13, 1998; 97(1): 16 - 18. [Full Text] [PDF]
|
|
|
|
|
|
C.J.M. Frijns, L.J. Kappelle, J. v. Gijn, H.K. Nieuwenhuis, J.J. Sixma, and R. Fijnheer Soluble Adhesion Molecules Reflect Endothelial Cell Activation in Ischemic Stroke and in Carotid Atherosclerosis Stroke, November 1, 1997; 28(11): 2214 - 2218. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Henninger, M. E. Gerritsen, and D. N. Granger Low-Density Lipoprotein Receptor Knockout Mice Exhibit Exaggerated Microvascular Responses to Inflammatory Stimuli Circ. Res., August 19, 1997; 81(2): 274 - 281. [Abstract] [Full Text]
|
|
|
|
|
|
M. F. Nageh, E. T. Sandberg, K. R. Marotti, A. H. Lin, E. P. Melchior, D. C. Bullard, and A. L. Beaudet Deficiency of Inflammatory Cell Adhesion Molecules Protects Against Atherosclerosis in Mice Arterioscler. Thromb. Vasc. Biol., August 1, 1997; 17(8): 1517 - 1520. [Abstract] [Full Text]
|
|
|
|
|
|
D. K. Vora, Z.-T. Fang, S. M. Liva, T. R. Tyner, F. Parhami, A. D. Watson, T. A. Drake, M. C. Territo, and J. A. Berliner Induction of P-Selectin by Oxidized Lipoproteins : Separate Effects on Synthesis and Surface Expression Circ. Res., June 19, 1997; 80(6): 810 - 818. [Abstract] [Full Text]
|
|
|
|
|
|
K. Peter, P. Nawroth, C. Conradt, T. Nordt, T. Weiss, M. Boehme, A. Wunsch, J. Allenberg, W. Kubler, and C. Bode Circulating Vascular Cell Adhesion Molecule-1 Correlates With the Extent of Human Atherosclerosis in Contrast to Circulating Intercellular Adhesion Molecule-1, E-Selectin, P-Selectin, and Thrombomodulin Arterioscler. Thromb. Vasc. Biol., March 1, 1997; 17(3): 505 - 512. [Abstract] [Full Text]
|
|
|
|
|
|
A. Sakai, N. Kume, E. Nishi, K. Tanoue, M. Miyasaka, and T. Kita P-Selectin and Vascular Cell Adhesion Molecule-1 Are Focally Expressed in Aortas of Hypercholesterolemic Rabbits Before Intimal Accumulation of Macrophages and T Lymphocytes Arterioscler. Thromb. Vasc. Biol., February 1, 1997; 17(2): 310 - 316. [Abstract] [Full Text]
|
|
|
|
|
|
P. K. Koskinen and K. B. Lemstrom Adhesion Molecule P-Selectin and Vascular Cell Adhesion Molecule–1 in Enhanced Heart Allograft Arteriosclerosis in the Rat Circulation, January 7, 1997; 95(1): 191 - 196. [Abstract] [Full Text]
|
|
|
|
|
|
M. Endres, U. Laufs, H. Merz, and M. Kaps Focal Expression of Intercellular Adhesion Molecule-1 in the Human Carotid Bifurcation Stroke, January 1, 1997; 28(1): 77 - 82. [Abstract] [Full Text]
|
|
|
|
|
|
G. W. Cockerill, K.-A. Rye, J. R. Gamble, M. A. Vadas, and P. J. Barter High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules Arterioscler. Thromb. Vasc. Biol., November 1, 1995; 15(11): 1987 - 1994. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Pan and R. P. McEver Regulation of the Human P-selectin Promoter by Bcl-3 and Specific Homodimeric Members of the NF-kappaB/Rel Family J. Biol. Chem., September 29, 1995; 270(39): 23077 - 23083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Falk, P. K. Shah, and V. Fuster Coronary Plaque Disruption Circulation, August 1, 1995; 92(3): 657 - 671. [Full Text]
|
|
|
|
|
|
K. J. Williams and I. Tabas The Response-to-Retention Hypothesis of Early Atherogenesis Arterioscler. Thromb. Vasc. Biol., May 1, 1995; 15(5): 551 - 561. [Full Text]
|
|
|
|
|
|
J. A. Berliner, M. Navab, A. M. Fogelman, J. S. Frank, L. L. Demer, P. A. Edwards, A. D. Watson, and A. J. Lusis Atherosclerosis: Basic Mechanisms : Oxidation, Inflammation, and Genetics Circulation, May 1, 1995; 91(9): 2488 - 2496. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
