help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dei Tos, A. P.
Right arrow Articles by Fletcher, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dei Tos, A. P.
Right arrow Articles by Fletcher, C. D.

American Journal of Pathology, Vol 145, 11-17, Copyright © 1994 by American Society for Investigative Pathology

REGULAR ARTICLES

Ultraviolet-induced p53 mutations in atypical fibroxanthoma

AP Dei Tos, R Maestro, C Doglioni, D Gasparotto, M Boiocchi, L Laurino and CD Fletcher
Department of Histopathology, City Hospital, Feltre, Italy.

Atypical fibroxanthoma (AFX) is an uncommon neoplasm of the superficial soft tissue occurring in actinically damaged skin of elderly patients. Sun-exposed skin also represents the main site of squamous and basal cell carcinomas and malignant melanoma, and a key role for ultraviolet (UV) radiation in their pathogenesis has long been suspected. UV- related mutations of the p53 gene have been identified in human skin cancers. To verify whether the pathogenesis of AFX is related to the effect of sunlight, p53 protein and gene status have been investigated in a series of 10 cases of AFX. Seven of 10 showed p53 immunoreactivity in most of the neoplastic cells. Molecular analysis of the p53 gene revealed an abnormal single strand conformation polymorphism pattern in all the p53 positive cases. Polymerase chain reaction direct sequencing revealed that all the mutations involved cytosine bases. Four cases showed C to T transitions (including two CC-TT double base substitutions) and two cases showed C to G transversion. All but one mutation took place at dipyrimidine sites. These findings provide the first objective evidence for the central role of UV radiation in the development of AFX and also represent the first in vivo demonstration of solar UV-induced mutations in a human mesenchymal neoplasm.


This article has been cited by other articles:


Home page
 BloodHome page
R. Maestro, A. Gloghini, C. Doglioni, S. Piccinin, T. Vukosavljevic, D. Gasparotto, A. Carbone, and M. Boiocchi
Human Non-Hodgkin's Lymphomas Overexpress a Wild-Type Form of p53 Which Is a Functional Transcriptional Activator of the Cyclin-Dependent Kinase Inhibitor p21
Blood, April 1, 1997; 89(7): 2523 - 2528.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R Maestro and M Boiocchi
Sunlight and melanoma: an answer from MTS1 (p16)
Science, January 6, 1995; 267(5194): 15 - 16.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American Society for Investigative Pathology.