help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lubke, U.
Right arrow Articles by Martin, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lubke, U.
Right arrow Articles by Martin, J. J.

American Journal of Pathology, Vol 145, 175-188, Copyright © 1994 by American Society for Investigative Pathology

REGULAR ARTICLES

Microtubule-associated protein tau epitopes are present in fiber lesions in diverse muscle disorders

U Lubke, J Six, M Villanova, J Boons, M Vandermeeren, C Ceuterick, P Cras and JJ Martin
Laboratory of Neuropathology, Born-Bunge Foundation, University of Antwerp, Wilrijk, Belgium.

The microtubule-associated protein tau is a major cytoskeletal protein involved in the neurofibrillary tangles of Alzheimer's disease. Although tau is predominantly a neuronal protein, it has been demonstrated in glia and other nonneuronal cells. We describe the presence of microtubule-associated protein tau epitopes in various muscle fiber lesions in oculopharyngeal and Becker muscular dystrophy, dermatomyositis, central core disease, neurogenic atrophy, and in the recovery phase of an attack of malignant hyperthermia. Western blot demonstrated a 100- to 110-kd tau-immunoreactive protein probably corresponding to 'big tau' as described in peripheral nerves. Tau immunoreactivity in muscle fiber lesions usually co-localized with tubulin, although electron microscopy failed to show an increase in microtubules. Tau and tubulin reactivity also correlated with the presence of desmin and vimentin epitopes. Possible explanations for the presence of tau are briefly discussed.


This article has been cited by other articles:


Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
H. Hattori, M. Matsumoto, K. Iwai, H. Tsuchiya, E. Miyauchi, M. Takasaki, K. Kamino, J. Munehira, Y. Kimura, K. Kawanishi, et al.
The {tau} Protein of Oral Epithelium Increases in Alzheimer's Disease
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2002; 57(1): M64 - 70.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American Society for Investigative Pathology.